Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications
Chemistry – A European Journal, Volume 32, Issue 12, 23 March 2026.Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley +1 more source
Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives
BiosensorsSmall molecules are highly relevant targets for detection and quantification. They are also used to diagnose and monitor the progression of disease and infectious processes and track the presence of contaminants.
Janine Kehrli +2 more
doaj +1 more source
Distance‐Dependent Energy Transfer Between Organic Fluorophores and Single‐Walled Carbon Nanotubes
Angewandte Chemie International Edition, Volume 65, Issue 12, 16 March 2026.We demonstrate that the dsDNA part adopts a perpendicular orientation to the SWCNT and present a distance‐dependent energy transfer of single fluorescent dyes to SWCNTs. Carbon nanotube energy transfer (CNET) obeys a d−5 distance dependence with a characteristic distance of 7.4 nm (± 0.7 nm) for 50 % energy transfer.
Izabela Kamińska +7 more
wiley +1 more source
Self‐Calibrating Ratiometric DNA Aptamer Probe for Quantitative ATP Imaging in Living Cells
Chemistry – A European Journal, Volume 32, Issue 11, 16 March 2026.We developed the RFA–ECHO probe, an internally calibrated ATP sensor that remains responsive across millimolar ATP levels. Its self‐correcting Cy5/ECHO ratio ensures accurate quantification independent of probe uptake. Compared with FRET‐based sensors, it yields a robust ratiometric shift, distinguishing high‐ATP cancer cells from normal ones, enabling
Yunsong Xu +5 more
wiley +1 more source
Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications
Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen +2 more
wiley +1 more source
RiboaptDB: A Comprehensive Database of Ribozymes and Aptamers
BMC Bioinformatics, 2006 Background Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that have been selected from vast populations of random sequences, through a combinatorial approach known as SELEX.
Thodima Venkata +2 more
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Light‐Up Sensing Citrate Using a Capture‐Selected DNA Aptamer
Advanced Sensor ResearchCitrate is a key metabolite and nutrient in humans. Its level is associated with many diseases from tumor growth to bone diseases. Detection of citrate has relied on its high negative charge, metal chelating properties and as an enzyme substrate. In this
Lide Gu +3 more
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Generation of high-affinity DNA aptamers using non-natural nucleotides [PDF]
Science-Business eXchange, 2013 openaire +1 more source
In silico conversion of ssRNA aptamers to ssDNA: molecular dynamics assessment of structural stability and conformational preservation. [PDF]
J Comput Aided Mol DesLorenti S +4 more
europepmc +1 more source
Abstract Discovery of functional nucleic acid ligands and catalytic motifs from a vast sequence space of randomized libraries is mostly based on time-consuming and demanding iterative rounds of in vitro selection.
Michal Hocek +12 more
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