Results 141 to 150 of about 581,942 (266)

2′-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP)

International Journal of Molecular Sciences, 2018
Lipopolysaccaride binding protein (LBP), a glycosylated acute phase protein, plays an important role in the pathophysiology of sepsis. LBP binds with high affinity to the lipid part of bacterial lipopolysaccaride (LPS).
Jasmin Aldag, T. Persson, R. Hartmann
semanticscholar   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Structural mechanism of insulin receptor activation by a dimeric aptamer agonist

Experimental and Molecular Medicine
Insulin binding to the insulin receptor (IR) triggers signaling pathways that regulate glucose uptake and cell growth. In previous work, we identified a DNA aptamer, A62, which partially activates the IR.
Junhong Kim, Hyeonjin Na, Si-Young Choi, Eun Ju Oh, Hyunsook Lee, Sung Ho Ryu, Na-Oh Yunn, Yunje Cho   +7 more
doaj   +1 more source

Enhancing the Sensitivity of Colorimetric Aptasensor Through Cd2+‐Thymine Interactions in ssDNA Loops for Food Contaminant Detection

Food Safety and Health, EarlyView.
This picture illustrates a novel aptamer‐based colorimetric assay, which demonstrates that high sensitivity, selectivity, and reliability for the rapid detection of cadmium ions (Cd2+) in water. Molecular dynamics (MD) simulations have revealed that the complexes are more stable, with Cd2+ binding more tightly to the thymine (T) within the aptamer loop.
Xuyan Li, Xinyu Ni, Yue Li, Xusheng Li, Dongbao Cai, Jianxia Sun, Chao Wang, Weibin Bai   +7 more
wiley   +1 more source

Three phases in the evolution of the standard genetic code: how translation could get started [PDF]

, 2007
A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like.
van der Gulik, Peter
core   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

The Graphene Oxide Memristive DNA Sensor for Taxonomic Fingerprint

Macromolecular Materials and Engineering, EarlyView.
A graphene oxide–based memristive DNA sensor enables rapid, label‐free quantification of nucleotide base composition across 37%–55% GC with strong linear calibration. Delivering results within 2–5 min, the platform combines high sensitivity with minimal sample preparation, offering a practical tool for point‐of‐care diagnostics, genetic fingerprinting,
Konstantin G. Nikolaev, Jia Hui Bong, Siyu Chen, Kostya S. Novoselov, Daria V. Andreeva   +4 more
wiley   +1 more source

Potential Use of DNA Aptamer-Magnetic Bead Separation-PCR Assay for Salmonella Detection in Food

Journal of Food Quality and Hazards Control, 2018
Background: Salmonella is one of the most common food-borne pathogens that can cause illness. In this study, the sensitivity and the specificity of Aptamer-Magnetic bead Separation-Polymerase Chain Reaction (AMS-PCR) method were determined for Salmonella
A.N. Zifruddin, K.L. Thong
doaj  

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Designer DNA‐Based Machines

SmartBot, EarlyView.
DNA machinery represents a burgeoning frontier at the intersection of robotics and nanotechnology, evolving from static nanostructure toward dynamic nanorobots. Here, the authors review the comprehensive research pipeline of designer DNA‐based nanomachines, covering the design, analysis, and fabrication. These programmable systems enable transformative
Yiquan An, Fan Wu, Yanyu Xiong, Cheng Zhang, Jian S. Dai, Lifeng Zhou   +5 more
wiley   +1 more source