Results 111 to 120 of about 49,590 (251)

WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy

Journal of Diabetes Investigation, EarlyView.
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen   +6 more
wiley   +1 more source

No Indication for APTT Screening in Patients on Oral Anticoagulant Therapy

, 1999
SummaryPatients on oral anticoagulant therapy (OAT) may bleed due to a very low factor IX level caused by a mutation at Ala-10 in the propeptide region of the factor IX gene.
Hans Vos, Frits Rosendaal, Felix van der Meer   +2 more
core   +1 more source

Preoperative Medical Evaluation and Optimisation of Children and Adolescents With Cerebral Palsy (GMFCS IV and V) With Complex Medical Comorbidity Undergoing Lower Limb Orthopaedic Surgery: Results of a Combined Rehabilitation Orthopaedic Paediatric Service

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To describe preoperative medical evaluation, optimisation and acute postoperative outcomes in children and adolescents with cerebral palsy (CP) undergoing lower limb orthopaedic surgery managed in a Combined Rehabilitation Orthopaedic Paediatric Service (CROPS). Methods A retrospective medical record review of children and adolescents with
Jennifer Armstrong, Emre Ilhan, Verity Pacey, Paula Bray, Matthias Axt, Jacqueline Dalby‐Payne   +5 more
wiley   +1 more source

Accuracy of a Bedside Heparin Anticoagulation Monitoring Test in Critically Ill Patients

Journal of Cardiovascular Development and Disease
Anticoagulation therapy with unfractionated heparin (UHF) is a mandatory treatment for many critically ill patients. While the gold standard for monitoring this therapy remains the laboratory-based aPTT (aPTT-lab), the need for immediate results has led ...
María Teresa Cruces Moreno, Raimundo García del Moral, Manuel Colmenero   +2 more
doaj   +1 more source

Oral Soft Tissue Biopsy in Patients Receiving Direct Oral Anticoagulants: A Prospective Cohort Study on Bleeding Outcomes

Oral Diseases, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are the first‐line therapy for stroke prevention in non‐valvular atrial fibrillation and venous thromboembolism. While evidence supports their continuation during routine dental procedures such as tooth extractions, data on oral soft tissue biopsies remain limited.
Rossana Izzetti, Chiara Cinquini, Antonio Barone, Marco Nisi   +3 more
wiley   +1 more source

Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Transfusion, EarlyView.
Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis or mortality. Design Prospective observational study of neonatal and pediatric ECMO patients from September 2016, until ...
Rebecca Barton, Suelyn Van Den Helm, Hui Ping Yaw, Chantal Attard, Graeme MacLaren, Vera Ignjatovic, Natasha Letunica, Vasiliki Karlaftis, Tengyi Cai, Amy Johansen, Derek Best, Roberto Chiletti, Yves d'Udekem, Jo McKittrick, Warwick Butt, Paul Monagle   +15 more
wiley   +1 more source

A retrospective study of the prevalence of isolated prolongation of activated partial thromboplastin time in the preoperative setting

JA Clinical Reports
Background Isolated prolongation of activated partial thromboplastin time (APTT) has various causes including inheritable bleeding disorders, and has medical significance as it can lead to the cancelation of surgery.
Yasuhiro Watanabe, Yuki Kato, Takayuki Matsuno   +2 more
doaj   +1 more source

Association between activated partial thromboplastin time and septic shock in pregnant women: a retrospective cohort study

Frontiers in Medicine
Maternal sepsis is a life-threatening infectious complication, with septic shock linked to high mortality. Coagulopathy is a key feature, but the association between activated partial thromboplastin time (APTT) and maternal septic shock remains unclear ...
Shengjia Zheng, Dunjin Chen, Dunjin Chen, Yuanmei Gao   +3 more
doaj   +1 more source

Hubungan Lama Menderita Diabetes Melitus dengan Kadar Prothrombin Time (PT) dan Activated Partial Thromboplastin Time (APTT) [PDF]

Latar Belakang : Hiperglikemia, hiperinsulinemia dan resistensi insulin telah terbukti dalamberbagai penelitian dapat menimbulkan perubahan terhadap berbagai komponen yang berperanterhadap faal hemostasis. Tujuan : Tujuan dari penelitian ini adalah untuk
Nikma, Nikma
core   +1 more source

Effect of HSA-NEPv on PT and APTT in rats.

, 2016
Mean (± SD) PT (A) and APTT (B) in rats after twice weekly administration of HSA-NEPv at dose levels of 0 (vehicle control), 5, 50 or 143 mg/kg for 1 month (n = 5 animals/gender/group). PT and APTT were measured on Day 26 (the day after the eighth dose).
Matthew Burrell (608638), Fritz Schweikart (3149958), Kenny M. Hansson (764733), Carl I. Webster (608637), Simon J. Henderson (3149967), Anna Ravnefjord (3149964), Susanne Witt (3149961), Susan B. Fowler (608640)   +7 more
core   +1 more source