Results 111 to 120 of about 45,024 (296)

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Management of Breakthrough Bleeding During Emicizumab Prophylaxis in Acquired Haemophilia A: Data From the GTH‐AHA‐EMI Study

Haemophilia, EarlyView.
ABSTRACT Introduction The GTH‐AHA‐EMI study showed that emicizumab reduces bleeding in patients with acquired haemophilia A (AHA). However, 22 clinically relevant new bleeds (CRNB) occurred in 14 of the 47 study patients, most of which required haemostatic treatment.
Halet Türkantoz, Christiane Dobbelstein, Richard Greil, Christina Hart, Robert Klamroth, Paul Knöbl, Johannes Oldenburg, Christian Pfrepper, Ulrich Sachs, Inga M. Schimansky, Karolin Trautmann‐Grill, Andreas Tiede   +11 more
wiley   +1 more source

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli, Arianna Gatti, Flora Ierna, Elena Riccardi, Irene Cuppari   +4 more
wiley   +1 more source

How I Investigate Borderline Prolonged aPTT: An Integrated Laboratory Approach to Mixing Studies and Factor Analysis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Borderline prolongation of routine clotting assays—particularly the activated partial thromboplastin time (aPTT)—is a common interpretative challenge in laboratory hematology. These reproducible but mildly prolonged results often lie just beyond the upper reference limit and can trigger unnecessary follow‐up, delays, or misinterpretation ...
Nikolaos Androulakis, Eleni Nioti, Antonios Dilintas, Christina Kalpadakis   +3 more
wiley   +1 more source

Significance of APTT as early predictor of bleeding in comparison to thrombocytopenia in dengue virus infection

, 2018
Background: Dengue is a systemic viral infection transmitted by mosquitoes such as Aedes aegypti or Aedes albopictus. Dengue Fever (DF) is characterized by fever, headache, muscle or joint pain, and rash.
S. V., Srinivasa, K., Prabhakar, A. G., Manoj, A., Raveesha, B. T., Hamsa   +4 more
core   +1 more source

Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Transfusion, EarlyView.
Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis or mortality. Design Prospective observational study of neonatal and pediatric ECMO patients from September 2016, until ...
Rebecca Barton, Suelyn Van Den Helm, Hui Ping Yaw, Chantal Attard, Graeme MacLaren, Vera Ignjatovic, Natasha Letunica, Vasiliki Karlaftis, Tengyi Cai, Amy Johansen, Derek Best, Roberto Chiletti, Yves d'Udekem, Jo McKittrick, Warwick Butt, Paul Monagle   +15 more
wiley   +1 more source

Accuracy of a Bedside Heparin Anticoagulation Monitoring Test in Critically Ill Patients

Journal of Cardiovascular Development and Disease
Anticoagulation therapy with unfractionated heparin (UHF) is a mandatory treatment for many critically ill patients. While the gold standard for monitoring this therapy remains the laboratory-based aPTT (aPTT-lab), the need for immediate results has led ...
María Teresa Cruces Moreno, Raimundo García del Moral, Manuel Colmenero   +2 more
doaj   +1 more source

Accuracy of aPTT monitoring in critically ill patients treated with unfractionated heparin

, 2014
The anticoagulant effect of unfractionated heparin (UFH) is usually monitored by means of the activated partial thromboplastin time (aPTT). In critically ill patients, however, increased levels of acute phase proteins may decrease the accuracy of the ...
Zwinderman, A. H., de Pont, A. C. J. M., Cheung, Y. W., van Roessel, S., Middeldorp, S.   +4 more
core  

Anaphylactic transfusion reaction to group B platelets related to alpha‐gal syndrome: A case report

Transfusion, EarlyView.
Abstract Background Alpha‐gal syndrome (AGS), a distinct form of IgE‐mediated hypersensitivity to the carbohydrate galactose‐α‐1,3‐galactose (α‐Gal), typically occurs after repeated tick bites and leads to allergic reactions after ingestion of mammalian meat.
Oscar Andre Hinojosa, Amitava Dasgupta, Zhan Ye   +2 more
wiley   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, EarlyView.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source