Results 91 to 100 of about 45,024 (296)

Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
In this meta‐analysis of 2 775 adult ECMO patients from non‐randomized studies, direct thrombin inhibitors and low‐molecular‐weight heparins demonstrated a favorable efficacy and safety profile over unfractionated heparin. These findings suggest them to be effective alternatives to unfractionated heparin, underscoring the urgent need for randomized ...
Vincenz Scharner, Karoline Lenz, Harald Herkner, Nina Buchtele, Thomas Staudinger, Eva Schaden, Marion Wiegele, Johannes Gratz   +7 more
wiley   +1 more source

APTT: A screening test for hypercoagulability in type 2 diabetes mellitus patients

, 2014
Background: Thrombosis is a common complication in Type 2 Diabetes Mellitus (T2DM). Prolonged APTT values have clinical relevance as an indicator of factor deficiency or the presence of coagulation inhibitors.
Korolova, L, Kwenda, J, Kaile, T, Mwambungu, A, Marimo, C   +4 more
core   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Milvexian in Healthy Chinese Adults

Drug Design, Development and Therapy
Zhu Luo,1 Jie Wang,2 Zhuolu Niu,3 Cuili Hu,4 Madhu Chintala,5 Xinchao Luo,3 Tsung-I Lee,3 Alexei N Plotnikov,5 Peter Zannikos5 1Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Hematology,
Luo Z, Wang J, Niu Z, Hu C, Chintala M, Luo X, Lee TI, Plotnikov AN, Zannikos P   +8 more
doaj  

Hypocoagulability among people living with HIV at Hoima Regional Referral Hospital, Western Uganda: a cross-sectional study

HIV Research & Clinical Practice
Background Coagulation abnormalities are an under-recognized complication among people living with HIV. Despite widespread antiretroviral therapy (ART), hematologic dysfunction, including coagulation and platelet abnormalities, continues to contribute to
Abdisalam Ahmed Sandeyl, Mohamed Jayte, Farah Dubad Abdi, Hassan Omar Ali, Abdisamad Guled Hersi, Zakarie Abdullahi Hussein, Venance Emmanuel Mswelo, Abdalla Ahmed Deifa, Abishir Mohamud Hirsi, Jacinto Amandua   +9 more
doaj   +1 more source

In Vitro Modeling of the Influence of FVIII Activity and Heparin Induced Prolongation of APTT

, 2008
Anticoagulant therapy is most commonly assessed by measuring the effect of the drug on global clotting assay, such as APTT. It is known that response of the APTT to hepa-rin may be decreased in patients with high levels of factor VIII.
Dženita Softić, Haračić, Midhat, Škrbo, Selma, Softić, Dženita, Aida Mehmedagić, Selma Škrbo, Midhat Haračić, Mehmedagić, Aida   +7 more
core   +1 more source

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Specificity and sensitivity of diluted aPTT and anticardiolipin antibodies towards thrombosis and miscarriages in patients with systemic lupus erythematosus

, 1990
In 36 patients suffering from systemic lupus erythematosus (SLE), lupus anticoagulant (LA), as assessed by aPTT and diluted aPTT, and anticardiolipin antibodies (aCL) were studied.
C. Quintarelli, FERRO, Domenico, SALIOLA, Mirella, CARLUCCI, Margherita, VIOLI, Francesco, VALESINI, Guido   +5 more
core   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically III children

Haematologica, 2007
The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal. Objective: Determine correlations of aPTT, anti-Xa and UFH dose in children.
Stefan Kuhle, Pablo Eulmesekian, Brian Kavanagh, Patricia Massicotte, Patsy Vegh, Alice Lau, Lesley G. Mitchell   +6 more
doaj   +1 more source