Results 81 to 90 of about 59,602 (254)

Inherited Bleeding Disorders in Pregnancy: Obstetric Management and Outcomes From a Tertiary Care Centre

Haemophilia, EarlyView.
ABSTRACT Objective This study aimed to evaluate the obstetric management, complications and clinical characteristics of pregnant women diagnosed with hereditary coagulation factor deficiencies at a tertiary obstetric centre over a 10‐year period. Methods We retrospectively reviewed a total of 19 pregnancies in 17 women with hereditary coagulation ...
Melis Altug Inan, Bilge Kapudere, Hanne Bulat Cim, Abdulkadir Turgut   +3 more
wiley   +1 more source

MECHANISM FOR SHORTENING PT AND APTT IN DOGS AND RATS-EFFECT OF FIBRINOGEN ON PT AND APTT-.

The Journal of Toxicological Sciences, 2003
The possible mechanisms for shortening prothrombin time (PT) and activated partial thromboplastin time (APTT) were investigated using citrated plasma from rats and dogs in vitro, especially focusing on increased fibrinogen concentrations. When purified canine fibrinogen was added to citrated canine plasma at final concentrations of 2, 4 and 8 mg/mL, PT
Masaaki, Kurata, Yukiko, Sasayama, Naoko, Yamasaki, Ikue, Kitazawa, Yoshimasa, Hamada, Ikuo, Horii   +5 more
openaire   +3 more sources

Application of Recombinant VII Activated Coagulation Factor for Children with Resistant Coagulopathy Caused Sepsis

Медицинский вестник Юга России, 2010
Purpose: To investigate the effectiveness of recombinant VII activated coagulation factor in complex therapy of children with resistant coagulopathy caused by sepsis. Materials and Methods: 38 children from 2 months to 17 years old were investigated with
N. Bgane, A. Trembach
doaj  

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Pathogenetic approach to the treatment of coagulopathic bleeding in obstetrics

Акушерство, гинекология и репродукция
Aim: to justify a differentiated approach to the treatment of obstetric coagulopathic bleeding depending on the nature of hemostasis disorders.Materials and Methods.
T. A. Sushko, M. S. Zainulina
doaj   +1 more source

Dried plasma retains hemostatic function and thermal stability during Arctic military operations

Transfusion, EarlyView.
Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh, Aron A. Shoara, Henry T. Peng, Viktor Prifti, Katy Moes, Cerys McGuinness, Tristan Bonnici, Maria Shiu, Sushmaa Chandralekha Selvakumar, Peter Andrisani, Pierre‐Marc Dion, Damien Miller, Sebastian Vuong, Colin A. Kretz, Philip J. Wallace, Shawn G. Rhind, Wendy Sullivan‐Kwantes, Andrew N. Beckett   +17 more
wiley   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Milvexian in Healthy Chinese Adults

Drug Design, Development and Therapy
Zhu Luo,1 Jie Wang,2 Zhuolu Niu,3 Cuili Hu,4 Madhu Chintala,5 Xinchao Luo,3 Tsung-I Lee,3 Alexei N Plotnikov,5 Peter Zannikos5 1Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Hematology,
Luo Z, Wang J, Niu Z, Hu C, Chintala M, Luo X, Lee TI, Plotnikov AN, Zannikos P   +8 more
doaj  

Hypocoagulability among people living with HIV at Hoima Regional Referral Hospital, Western Uganda: a cross-sectional study

HIV Research & Clinical Practice
Background Coagulation abnormalities are an under-recognized complication among people living with HIV. Despite widespread antiretroviral therapy (ART), hematologic dysfunction, including coagulation and platelet abnormalities, continues to contribute to
Abdisalam Ahmed Sandeyl, Mohamed Jayte, Farah Dubad Abdi, Hassan Omar Ali, Abdisamad Guled Hersi, Zakarie Abdullahi Hussein, Venance Emmanuel Mswelo, Abdalla Ahmed Deifa, Abishir Mohamud Hirsi, Jacinto Amandua   +9 more
doaj   +1 more source

Endothelial thrombomodulin—Its role in trauma‐induced coagulopathy

Transfusion, EarlyView.
Abstract Background Trauma‐induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin‐protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes.
Jeries Abu‐Hanna, Gael B. Morrow, Gang Xu, Lewis Timms, Naveed Akbar, Michael Laffan, Robin P. Choudhury, Nicola Curry   +7 more
wiley   +1 more source