Results 71 to 80 of about 49,590 (251)

Initial V‐A ECMO Flow‐Index and Its Association With Inflammation, Organ Failure, and Outcomes

Artificial Organs, EarlyView.
Higher initial V‐A ECMO flow‐index was associated with greater shock severity and independently associated with multi‐organ failure. Early hemolysis may partly contribute to this association, particularly in eCPR patients, whereas no significant indirect effect through IL‐6 was observed.
Kostiantyn Kozakov, Zdenek Provaznik, Alois Philipp, Maik Foltan, Christian Schach, Sergey Vasin, Andreas Keyser, Leopold Rupprecht, Christof Schmid, Simon Schopka   +9 more
wiley   +1 more source

Epidemiological association between fasting plasma glucose and shortened APTT

, 2009
Objectives: To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis.
Favaloro E.J., GUIDI, Giancesare, SALVAGNO, GIAN LUCA, LIPPI, Giuseppe, TARGHER, Giovanni, Franchini M, MONTAGNANA, Martina   +6 more
core   +1 more source

PENGARUH PENDIAMAN DARAH SITRAT PADA SUHU 2-8°C TERHADAP NILAI ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) [PDF]

, 2022
Latar Belakang: Pemeriksaan APTT (Activated Partial Thromboplastin Time) adalah pemeriksaan rutin hemostasis yang digunakan untuk mengevaluasi mekanisme pembekuan darah pasien pada jalur instrinsik dan jalur bersama.
Afifah, Destine
core  

Meriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study

Journal of Experimental Pharmacology, 2022
Filmon Kiflezghi Kiflemariam,1 Abiel Ghebrehiwet Tewelde,1 Ali Mahmud Hamid,1 Bilal Mussa Beshir,1 Samrawit Negasi Solomon,1 Tesfu Gonets Eman,1 Daniel Mebrahtu Abraha,1,2 Russom Kahsu,1 John Issac,1 Jeevan Jyoti Kaushik1 1Department of Clinical ...
Kiflemariam FK, Tewelde AG, Hamid AM, Beshir BM, Solomon SN, Eman TG, Abraha DM, Kahsu R, Issac J, Kaushik JJ   +9 more
doaj  

Time- and Temperature-Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management. [PDF]

J Clin Lab Anal
This in vitro workflow illustrates the time‐and temperature‐dependent behavior of acquired FV inhibitors. Patient plasma was centrifuged and serially diluted, followed by parallel incubation at room temperature and 37°C. Serial measurements of APTT mixing test and residual FV activity were recorded across incubation time points to monitor inhibitor ...
Zhang L, Li M, Xie Z, Yao J, Cao Y, Chen L, Wang M.   +6 more
europepmc   +2 more sources

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad, Elin Pålsson, Vladimir Lazarevic, Leila Naddi, Ola Borgquist, Lars Nilsson, Maria Adrian, Björn P. Bark, Thomas Kander   +8 more
wiley   +1 more source

How to choose the suitable reagent for APTT screening test

, 2018
Bakalářská práce se zabývá výběrem správné reagencie pro stanovení koagulačního screeningového testu aktivovaného parciálního tromboplastinového času (APTT).
Samková, Dominika
core  

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source