Results 141 to 150 of about 83,758 (359)

Integration of Efanesoctocog Alfa in Clinical Practice for Children, Adolescents, and Young Adults With Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa is a novel, “ultra‐extended half‐life” FVIII concentrate for bleed treatment and prevention in haemophilia A. Clinical trials excluded individuals with active or prior FVIII inhibitors, those on emicizumab, and previously untreated patients (PUPs).
Debbie Jiang, Natalie Johnston, Daniel Echelman, Stacy E. Croteau   +3 more
wiley   +1 more source

Investigation of active matrix- metaloproteinase-8 (aMMP-8) as a reference parameter for path control in antimicrobial photothermal therapy (aPTT) using a split-mouth design [PDF]

, 2019
Jeannette Deumer, Matthias Frentzen, Martina C. Meinke   +2 more
openalex   +1 more source

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

A Case of Factor XIII Deficiency Identified by Recurrent Postoperative Bleeding After Tonsillectomy [PDF]

Clin Case Rep
ABSTRACT Postoperative bleeding is a well‐known complication of tonsillectomy. Although inadequate hemostasis and vascular injury are common causes, occult coagulation disorders may also contribute. Factor XIII deficiency is an extremely rare condition that is particularly difficult to detect preoperatively because PT and APTT typically remain normal ...
Teramura T, Sakai A, Hamada M, Wasano K, Yamamoto A, Yamamoto H, Okami K.   +6 more
europepmc   +2 more sources

Usefulness of Cumulative Summation of Differences Method for Determining APTT Reagent Suitability [PDF]

, 2012
Susan H. Findlater
openalex   +1 more source

A Retrospective Study of Adult and Pediatric D‐Dimer Tests to Identify Opportunities for Improved Utilization

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood, Hassan Abu Sabah, Natalie Mathews, James Douketis, Catherine Hayward   +4 more
wiley   +1 more source

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]

, 2018
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo, Ceunynck, Karen De, Chaudhry, Sharjeel A., Dockendorff, Chris, Fitch-Tewfik, Jennifer L., Flaumenhaft, Robert, Higgins, Sarah J., Ingber, Donald E., Jain, Abhishek, Parikh, Samir M., Peters, Christian G.   +10 more
core   +1 more source

Assessment of intrathecal therapy in the treatment of familial haemophagocytic lymphohistiocytosis

British Journal of Haematology, EarlyView.
Katarina Zivkovic, Elisabet Bergsten, Maurizio Aricó, Itziar Astigarraga, Eiichi Ishii, Stephan Ladisch, Kai Lehmberg, Milen Minkov, Vasanta Nanduri, Jan‐Inge Henter   +9 more
wiley   +1 more source

Impact of Early Surgery on Clinical Outcomes of Super‐Aged Patients With Hip Fractures: A Retrospective Propensity Score‐Matched Study With 2‐Year Follow‐Up

Orthopaedic Surgery, EarlyView.
Early surgery (< 48 h) in super‐aged hip fracture patients reduces 1–2 years mortality, complications, hospital stay, and costs, supporting timely intervention protocols. ABSTRACT Objective The global aging population has led to a significant increase in hip fractures among elderly patients, posing substantial clinical challenges.
Tian Xie, Chen Rui, Wang Gao, Yucheng Gao, Chuwei Tian, Liu Shi, Wenbin Fan, Hui Chen, Yunfeng Rui   +8 more
wiley   +1 more source