Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the “analytical quality by design” approach [PDF]
, 2020 A UPLC-MS method for the estimation of atazanavir sulfate was developed using the “analytical quality by design” approach. The critical chromatographic quality attributes identified were retention time, theoretical plates and peak tailing.
CHANDAN RAVANDUR SHIVANNA +2 more
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New insights on the matter-gravity coupling paradigm
, 2012 The coupling between matter and gravity in General Relativity is given by a proportionality relation between the stress tensor and the geometry. This is an oriented assumption driven by the fact that both the stress tensor and the Einstein tensor are ...
Jan Steinhoff +3 more
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Journal of Applied Pharmaceutical ResearchBackground: Drugs like Amphotericin B and Luliconazole, which are poorly soluble in water and undergo significant first-pass metabolism, often show low bioavailability.
Pravin N. Kirdat, Meenakshi B. Patel
doaj +1 more source
Surface singularities in Eddington-inspired Born-Infeld gravity
, 2012 Eddington-inspired Born-Infeld gravity was recently proposed as an alternative to general relativity that offers a resolution of spacetime singularities. The theory differs from Einstein's gravity only inside matter due to nondynamical degrees of freedom,
Pani, Paolo, Sotiriou, Thomas P.
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Software-assisted analytical Quality by Design for stability-indicating method development: integration of DoE and predictive retention modeling using MODDE® and DryLab® [PDF]
Makedonsko Farmacevtski BiltenIn modern pharmaceutical development, the increasing complexity of drug substances, formulations, and regulatory expectations has rendered traditional one-factor-at-a-time (OFAT) approaches to analytical method development inefficient and increasingly ...
Dino Karpicarov +5 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2021 Background The current study describes the use of central composite design for multivariate optimization of resolution and retention time, taking into account different critical method parameters like organic phase, pH, flow rate, and wavelength for risk
Rama Tulasi Jampana +2 more
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Flavor Symmetries and The Problem of Squark Degeneracy
, 1993 If supersymmetry exists at low energies, it is necessary to understand why the squark spectrum exhibits sufficient degeneracy to suppress flavor changing neutral currents.
A. Kagan +34 more
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Quality-by-design in pharmaceutical development: From current perspectives to practical applications [PDF]
, 2021 Current pharmaceutical research directions tend to follow a systematic approach in the field of applied research and development. The concept of quality-by-design (QbD) has been the focus of the current progress of pharmaceutical sciences. It is based on,
BOGLÁRKA KOVÁCS-DEÁK +6 more
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Determination of Bupropion and Its Impurities via a Chaotropic Chromatography Method Following Analytical Quality-by-Design Principles for Method Development [PDF]
, 2022 A novel chaotropic chromatography method for the quantitative determination of bupropion and its impurities, following analytical quality-by-design (AQbD) principles, is presented.
Dotsikas, Yannis +2 more
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Hidden Q-structure and Lie 3-algebra for non-abelian superconformal models in six dimensions
, 2014 We disclose the mathematical structure underlying the gauge field sector of the recently constructed non-abelian superconformal models in six spacetime dimensions. This is a coupled system of 1-form, 2-form, and 3-form gauge fields.
Lavau, Sylvain +2 more
core +3 more sources