Results 71 to 80 of about 833 (196)

Analytical quality by design using a D-optimal design and parallel factor analysis in an automatic solid phase extraction system coupled to liquid chromatography. Determination of nine PAHs in coffee samples [PDF]

, 2023
Optimizing a multi-residue analysis when using an automatic SPE (solid phase extraction) system and complex matrices becomes a difficult problem because of the large number of experimental factors that can influence the recovery of the analytes ...
Arce Antón, Mar, Ortiz Fernández, Mª Cruz, Sarabia Peinador, Luis Antonio, Valverde Som, Lucía   +3 more
core   +1 more source

Sustainable RP‐HPLC Approach for Profiling Pioglitazone and Related Substances

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A sustainable RP‐HPLC method for the comprehensive fingerprinting of pioglitazone and its related substances was developed and validated in alignment with green analytical chemistry principles. Utilizing eco‐friendly solvents and reducing waste generation were used to optimize chromatographic conditions.
Tahani Y. A. Alanazi, Samar M. Mahgoub, Fahad M. Alminderej, Yasmeen G. Abou El-Reash, Omkulthom Al kamaly, Sayed M. Saleh, Mahmoud A. Mohamed, Munmun Bardhan   +7 more
wiley   +1 more source

Development and Validation of Quality by Design‐Based HPLC Method for Impurity Profiling of Alprazolam

SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.
ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa, Venkata Ratnam K., Venkata Nadh Ratnakaram, Sunil Dhuri, Bondigalla Ramachandra   +4 more
wiley   +1 more source

Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method

International Journal of Analytical Chemistry, 2021
The use of analytical quality by design (AQbD) approach in the optimization of the high-performance liquid chromatography (RP-HPLC) method is a novel tool.
Nabil K. Alruwaili
doaj   +1 more source

A Boundary Term for the Gravitational Action with Null Boundaries

, 2016
Constructing a well-posed variational principle is a non-trivial issue in general relativity. For spacelike and timelike boundaries, one knows that the addition of the Gibbons-Hawking-York (GHY) counter-term will make the variational principle well ...
Chakraborty, Sumanta, Majhi, Bibhas Ranjan, Padmanabhan, T., Parattu, Krishnamohan   +3 more
core   +1 more source

Analytical Quality by Design‐Based Stability‐Indicating UHPLC Method for Determination of Inavolisib in Bulk and Formulation

SEPARATION SCIENCE PLUS, Volume 8, Issue 8, August 2025.
ABSTRACT Inavolisib is a novel, potent, and selective phosphatidylinositol‐3‐kinase alpha inhibitor recently approved for the treatment of phosphatidylinositol‐3‐kinase alpha‐mutated breast cancer. This research focuses on the UHPLC method development and method validation of a stability‐indicating RP‐UHPLC method for the quantification of inavolisib ...
Ashwinkumar matta, Raja Sundararajan
wiley   +1 more source

AQbD-Assisted Development and Validation of RP-HPLC Method for Simultaneous Quantification of Remogliflozin Etabonate, Vildagliptin, and Metformin Hydrochloride in Single Formulation [PDF]

Introduction:The study aimed to optimize and validate a Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method for the simultaneous quantification of Remogliflozin Etabonate (REM), Vildagliptin (VIL), and Metformin Hydrochloride (MET) in a
Jigar A. Shah, Dr. B.N. Suhagia
core   +2 more sources

Quality by Design Based Chromatography Technique Development and Validation for the Medicine Venetoclax (for Chronic Leukemia), in the Context of Impurities Including Degradation Products

Biomedical Chromatography, Volume 39, Issue 5, May 2025.
ABSTRACT The present research study describes the Venetoclax (VEN)‐related substances test method using RP‐HPLC/DAD techniques. It was developed and validated according to ICH Q14 and Q2(R2) guidelines. The substances were separated using an X‐Bridge Phenyl column (150 mm × 4.6 mm, 3.5 μm) and a gradient program.
Rajeshwari Dandabattina, Karuna Sree Merugu, Lova Gani Raju Bandaru, Haridasyam Sharathbabu, Rambabu Gundla, Naresh Kumar Katari   +5 more
wiley   +1 more source

Green Analytical Stability Indicating UHPLC Method for the Quantification of Related Impurities in Vonoprazan Formulation Applying Analytical Quality by Design

SEPARATION SCIENCE PLUS, Volume 8, Issue 4, April 2025.
ABSTRACT Vonoprazan is an innovative potassium competitive acid blocker and has emerged as an effective alternative to proton pump inhibitors for the treatment of acid‐related disorders. High‐performance liquid chromatography was performed using a Symmetry C18 column (150 mm × 4.6 mm ID, 3.0 µm) with a mobile phase flow rate of 1.0 mL/min. Mobile phase
Ashwinkumar Matta, Raja Sundararajan
wiley   +1 more source

New Variables for Classical and Quantum Gravity in all Dimensions II. Lagrangian Analysis

, 2013
We rederive the results of our companion paper, for matching spacetime and internal signature, by applying in detail the Dirac algorithm to the Palatini action.
A Thurn, Alexandrov S, Anishetty R, Ashtekar A, Ashtekar A, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Dirac P A M, Freidel L, Freidel L, Giesel K, Henneaux M, Livine E R, N Bodendorfer, Peldan P, Rovelli C, T Thiemann, Thiemann T   +21 more
core   +1 more source