A sigma model field theoretic realization of Hitchin's generalized complex geometry
, 2004 We present a sigma model field theoretic realization of Hitchin's generalized complex geometry, which recently has been shown to be relevant in compactifications of superstring theory with fluxes.
A. Kapustin +18 more
core +5 more sources
Robust optimization of gradient RP HPLC method for simultaneous determination of ivabradine and its eleven related substances by AQbD approach [PDF]
, 2021 This paper is aimed at developing a gradient elution reversed-phase high-performance liquid chromatography (RP-HPLC) method for the separation of a complex mixture composed of ivabradine and its eleven impurities, in a reasonable timeframe.
Agbaba, Danica +5 more
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Surface singularities in Eddington-inspired Born-Infeld gravity
, 2012 Eddington-inspired Born-Infeld gravity was recently proposed as an alternative to general relativity that offers a resolution of spacetime singularities. The theory differs from Einstein's gravity only inside matter due to nondynamical degrees of freedom,
Pani, Paolo, Sotiriou, Thomas P.
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Journal of Applied Pharmaceutical ResearchBackground: Drugs like Amphotericin B and Luliconazole, which are poorly soluble in water and undergo significant first-pass metabolism, often show low bioavailability.
Pravin N. Kirdat, Meenakshi B. Patel
doaj +1 more source
New insights on the matter-gravity coupling paradigm
, 2012 The coupling between matter and gravity in General Relativity is given by a proportionality relation between the stress tensor and the geometry. This is an oriented assumption driven by the fact that both the stress tensor and the Einstein tensor are ...
Jan Steinhoff +3 more
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Analytical Method Validation: A Comprehensive Review of Current Practices [PDF]
Analytical method validation is a critical process in industries such as pharmaceuticals, food safety, biotechnology, and environmental monitoring. It guarantees reliability, reproducibility, and compliance with regulatory obligations. This review covers
Sachin S. Shinde, Dr. Preeti Khulbe
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Determination of Bupropion and Its Impurities via a Chaotropic Chromatography Method Following Analytical Quality-by-Design Principles for Method Development [PDF]
, 2022 A novel chaotropic chromatography method for the quantitative determination of bupropion and its impurities, following analytical quality-by-design (AQbD) principles, is presented.
Dotsikas, Yannis +2 more
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Flavor Symmetries and The Problem of Squark Degeneracy
, 1993 If supersymmetry exists at low energies, it is necessary to understand why the squark spectrum exhibits sufficient degeneracy to suppress flavor changing neutral currents.
A. Kagan +34 more
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Software-assisted analytical Quality by Design for stability-indicating method development: integration of DoE and predictive retention modeling using MODDE® and DryLab® [PDF]
Makedonsko Farmacevtski BiltenIn modern pharmaceutical development, the increasing complexity of drug substances, formulations, and regulatory expectations has rendered traditional one-factor-at-a-time (OFAT) approaches to analytical method development inefficient and increasingly ...
Dino Karpicarov +5 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2021 Background The current study describes the use of central composite design for multivariate optimization of resolution and retention time, taking into account different critical method parameters like organic phase, pH, flow rate, and wavelength for risk
Rama Tulasi Jampana +2 more
doaj +1 more source