Results 91 to 100 of about 41,663 (295)

Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase 3β-positive epithelium [PDF]

, 2012
It was hypothesized that lithium causes accelerated and permanent injury to the postnatally developing kidney through entry into epithelial cells of the distal nephron and inhibition of glycogen synthase kinase-3β (GSK-3β).
Christensen, Sten, Jensen, Boye L, Kjaersgaard, Gitte, Madsen, Kirsten, Marcussen, Niels, Walter, Steen   +5 more
core   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Aquaporins: important but elusive drug targets. [PDF]

, 2014
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients.
A Bergamo, A Burykin, A Kimura, A Rossi, A Warth, A Warth, AB Chepelinsky, AJ Smith, AJ Yool, AJ Yool, Alan S. Verkman, AP Martins, AP Martins, AS Verkman, AS Verkman, B Bassarak, B Bertrand, B Ma, B Yang, B Yang, B Yang, B Yang, B Zhang, BC Kieseier, BJ Baum, BJ Baum, BJ Jin, BK Tamarappoo, BL de Groot, C Esteva-Font, C Goubau, C Maurel, CL Chou, CM Niemietz, D Fu, D Fu, D Seeliger, D Wesche, D Zhang, DC Blaydon, DG Bichet, DK Binder, DM Wingerchuk, E Beitz, E Lindahl, E Migliati, E Solenov, E Soupene, EM Muller, EM Nagy, ET Olesen, EW Miller, F Baumgart, FJ Detmers, G Di Giusto, G Fischer, G Soveral, G Soveral, GM Preston, GM Preston, GP Bienert, GP Nicchia, GT Manley, H Chen, H Hasegawa, H Sui, H Tsukaguchi, H Zhang, HJ Jung, HL Brooks, J Badaut, J Farinas, J Farinas, J Farinas, J Gao, J Hu, J Li, J Li, J Liu, J Palace, J Schnermann, JD Ho, JE Rash, JF Kun, JJ Iliff, JJ Irwin, JL Edelman, JM Crane, JP Morello, JR Thiagarajah, JS Hub, K Ishibashi, K Miranda, K Murata, K Oshio, K Oshio, K Oshio, KI Auguste, L Janosi, L Tradtrantip, L Tradtrantip, L Tradtrantip, L Tradtrantip, LJ Galietta, LM Holm, LS King, M Amiry-Moghaddam, M Araki, M Boone, M Dumas, M Endo, M Hara, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Herrera, M Kato, M Moore, M Ozu, M Ozu, Marc O. Anderson, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MG Mola, MH Levin, MH Levin, MJ Tait, MP Marrades, N Chihara, N Maeda, N Roudier, N Roudier, N Zhu, NN Haj-Yasein, O Bloch, O Bloch, P Padmawar, PM Deen, PW Phuan, R Gao, R Katada, R Musa-Aziz, R Zhang, RB Zhang, RI Macey, S Jelen, S Jelen, S Nielsen, S Nielsen, S Pavlovic-Djuranovic, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Sasaki, S Tornroth-Horsefield, SD Shields, SJ Wacker, SR Hinson, SR Hinson, T Gonen, T Hibuse, T Ma, T Ma, T Ma, T Ma, T Ma, T Yamamoto, T Zeuthen, TH Kwon, TL Pallone, V Berry, VA Lennon, VA Lennon, VJ Huber, VJ Huber, W Castro-Borges, X Cao, Y Liu, Y Morishita, Y Song, Y Song, Y Wang, YB Zhang, YH Huang, Z Zhang, ZH Li   +194 more
core   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Neuromyelitis optica - an update: 2007-2009

Annals of Indian Academy of Neurology, 2009
Neuromyelitis optica is an inflammatory demyelinating disorder of the central nervous system. The discovery of a specific antibody (NMO IgG /aquaporin-4 antibody) in patients with this condition has led to a marked revival of research on the disease ...
Jacob Anu
doaj  

COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction [PDF]

, 2007
  Udgivelsesdato: 2007-MayRelease of bilateral ureteral obstruction (BUO) is associated with reduced expression of renal aquaporins (AQPs), polyuria, and impairment of urine-concentrating capacity. Recently, we demonstrated that 24 h of BUO is associated
Diget, Maria, Frøkiaer, Jørgen, Jensen, Boye L, Knepper, Mark A, Nielsen, Søren, Nørregaard, Rikke, Schweer, Horst, Topcu, Sukru Oguzkan   +7 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Frontiers in Physiology, 2018
Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-
Devishree Krishnan, Devishree Krishnan, Wanling Pan, Megan R. Beggs, Megan R. Beggs, Francesco Trepiccione, Régine Chambrey, Régine Chambrey, Dominique Eladari, Dominique Eladari, Emmanuelle Cordat, Emmanuelle Cordat, Henrik Dimke, R. Todd Alexander, R. Todd Alexander, R. Todd Alexander   +15 more
doaj   +1 more source

Protein quality control: the who's who, the where's and therapeutic escapes [PDF]

, 2018
In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm.
Fan, Jingyu, Gaplovska-Kysela, Katarina, Guhl, Bruno, Hirano, Kiyoko, Le Fourn, Valerie, Roth, Jürgen, Santimaria, Roger, Torossi, Tania, Yam, Gary, Ziak, Martin, Zuber, Christian   +10 more
core  

UT-B-deficient mice develop renal dysfunction and structural damage [PDF]

, 2012
Background: Urea transporter UT-B is the major urea transporter in erythrocytes and the descending vasa recta in the kidney. In this study, we investigated the effects of long-term UT-B deficiency on functional and structural defect in the kidney of 16 ...
Lei Zhou, Yan Meng, Tianluo Lei, Dan Zhao, Jing Su, Xuejian Zhao, Baoxue Yang   +6 more
core   +2 more sources