Results 111 to 120 of about 41,663 (295)

Gi Protein Modulation of the Potassium Channel TASK-2 Mediates Vesicle Osmotic Swelling to Facilitate the Fusion of Aquaporin-2 Water Channel Containing Vesicles

Cells, 2018
Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content.
Mariangela Centrone, Maria Penelope De Santo, Isabella Nicotera, Cristina Labate, Marianna Ranieri, Annarita Di Mise, Maria Grazia Mola, Maria Mastrodonato, Rosangela Elliani, Riccardo Barberi, Vincenzo Formoso, Grazia Tamma, Giovanna Valenti   +12 more
doaj   +1 more source

Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux [PDF]

, 2013
SUMMARY Many unicellular tubes such as capillaries form lumens intracellularly, a process that is not well understood. Here we show that the cortical membrane organizer ERM-1 is required to expand the intracellular apical/lumenal membrane and its actin ...
A Fire, A Hahn-Windgassen, A Tamura, A Vasilyev, AJ MacQueen, AK Mah, B Cha, B Lubarsky, BC Mattingly, BE Kerman, C Hachez, C Maurel, CC Mello, CG Huang, D Brown, D Chirivino, D Deretic, David H. Hall, DH Hall, DM Bryant, DN Mastronarde, DT Stinchcomb, E Harlow, EA Perens, FK Nelson, G Hadwiger, G Lamprecht, G Tamma, GM Preston, H Sugiya, H Winkler, HI Cheong, Hongjie Zhang, I Abdus-Saboor, I Saotome, J Folkman, J Liu, J Schottenfeld-Roames, JJ Tung, John T. Fleming, JP Ten Klooster, JR Kremer, K Nozaki, K Tatsumi, KL Berry, L Gervais, L Herwig, L Timmons, L Zhu, Lei Sun, Liakot A. Khan, LS King, M Bagnat, M Bagnat, M Buechner, M Buechner, M Fujita, M Kaksonen, M Kamei, M Koppen, Matthew Buechner, ME Desmond, MP Stewart, N Suzuki, Nessy Abraham, P Agre, R Zhou, RG Fehon, RM Weimer, S Brenner, S Saadoun, SJ Cho, SJ Jones, SP Denker, T Gonen, T Krupinski, V Gobel, Verena Gobel, Y Chen, Y Morishita, Y Wang, Z Balklava, Z Wang   +82 more
core   +3 more sources

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Antidepressants and the risk of hyponatremia: A multi‐institutional cohort study using observational medical outcomes partnership—Common Data Model

British Journal of Clinical Pharmacology, EarlyView.
Aim Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety. Methods Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003–2023 ...
Kyungyeon Jung, Ju Hwan Kim, Da Eun Hyeon, Jeongmoon Ji, Min Young Lee, Hayun Choi, Dong Yun Lee, Min Woo Kim, Yoonmin Jang, Seonghoon Hwang, Jaehyeong Cho, Seok Young Song, Sang Youl Rhee, Jae Myung Cha, Won‐Woo Seo, Chang‐Won Jeong, Seung‐Jin Kwag, Woo Jin Kim, Jaeuk Hwang, Min‐ho Kim, Rae Woong Park, Ju‐Young Shin   +21 more
wiley   +1 more source

Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Water Channel Aquaporin-2 of Kidney Collecting Duct Cells

Journal of Pharmacological Sciences, 2004
Aquaporin-2 (AQP2) is one of the membrane water channel proteins expressed in principal cells of the kidney collecting ducts. In the basal state, AQP2 resides in the storage vesicles localized in the subapical cytoplasm. Upon stimulation with vasopressin,
Kuniaki Takata, Yuki Tajika, Toshiyuki Matsuzaki, Takeo Aoki, Takeshi Suzuki, Ablimit Abduxukur, Haruo Hagiwara   +6 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Assessing biomimetic aquaporin membrane for forward osmosis desalination process: A dataset

Data in Brief, 2019
This paper presents the performance of aquaporin forward osmosis membrane using chemical fertilizers as a draw solution. The comprehensive evaluation conducted for five conventional fertilizers ((CO (NH2)2, KCl, CaCl2, (NH4)2SO4) and (NH4)2HPO4) as draw ...
Soleyman Sahebi, Nasim Fadaie, Leila Mirshekar, Bahram Kamarehie, Toraj Mohammadi   +4 more
doaj   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Unique Regulation of AQP1 and AQP5 Expression by HIF-1 in Nucleus Pulposus Cells

Global Spine Journal, 2014
Introduction Aquaporins are a family of transmembrane water channels that aid in osmoregulation, a critical function in the proteoglycan-rich nucleus pulposus. Previous reports have demonstrated expression of aquaporins in the intervertebral disc.
S. Gogate, Z. Johnson, R. Day, A. Binch, D. Markova, N. Chiverton, A. Cole, M. Conner, I. Shapiro, C. L. Le Maitre, M. Risbud   +10 more
doaj   +1 more source

CHD1L: a new candidate gene for congenital anomalies of the kidneys and urinary tract (CAKUT) [PDF]

, 2017
Background. Recently, we identified a microduplication in chromosomal band 1q21.1 encompassing the CHD1L/ALC1 gene encoding a chromatin-remodelling enzyme in congenital anomalies of the kidneys and urinary tract (CAKUT) patient. Methods.
Brockschmidt, Antje, Christ, Laura, Chung, Boidinh, Fischer, Dagmar-Christiane, Haffner, Dieter, Heimbach, André, Klaus, Günter, Kolatsi-Joannou, Maria, Konrad, Martin, Schaefer, Franz, Shtiza, Diamant, Simonetti, Giacomo D., Weber, Ruthild G., Weber, Stefanie, Winyard, Paul   +14 more
core