Results 51 to 60 of about 75,608 (261)
Inhibitors of Mammalian Aquaporin Water Channels
International Journal of Molecular Sciences, 2019 Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and
Mohammed Abir-Awan +5 more
semanticscholar +1 more source
Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Patients carrying the carbonic anhydrase12 E143K mutation showed the dry mouth phenotype. The mechanism underlying the modulation of aquaporin 5 and function in the salivary glands by carbonic anhydrase12 remains unknown. In this study, we identified the
Soyoung Hwang +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 The highly invasive nature of glioblastoma imposes poor prospects for patient survival. Molecular evidence indicates glioblastoma cells undergo an intriguing expansion of phenotypic properties to include neuron-like signaling using excitable membrane ion
Andrea J. Yool +2 more
doaj +1 more source
Modified Kedem-Katchalsky equations for osmosis through nano-pore
, 2016 This work presents a modified Kedem-Katchalsky equations for osmosis through nano-pore. osmotic reflection coefficient of a solute was found to be chiefly affected by the entrance of the pore while filtration reflection coefficient can be affected by ...
Huang, Suyi +6 more
core +1 more source
Multiscale modelling of fluid and solute transport in soft tissues and microvessels [PDF]
, 2010 This study focuses on the movement of particles and extracellular fluid in soft tissues and microvessels. It analyzes modeling applications in biological and physiological fluids at a range of different length scales: from between a few tens to several ...
Lu, Yiling, Wang, Wen
core +2 more sources
Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica
Journal of Neurology Neurosurgery & Psychiatry, 2016 Objective Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility.
P. Waters +44 more
semanticscholar +1 more source
Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif +17 more
wiley +1 more source
Frontiers in Human Neuroscience, 2022 A comprehensive understanding of the cerebrospinal fluid (CSF) system is essential for our understanding of health and disease within the central nervous system (CNS).
Thea Overgaard Wichmann +2 more
doaj +1 more source
Volume changes during active shape fluctuations in cells [PDF]
, 2015 Cells modify their volume in response to changes in osmotic pressure but it is usually assumed that other active shape variations do not involve significant volume fluctuations.
Kardash, Elena +5 more
core +2 more sources
Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz +8 more
wiley +1 more source