Results 81 to 90 of about 75,608 (261)

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

Molecular Neurodegeneration, 2015
BackgroundPreventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain ...
Zhiqiang Xu, Na Xiao, Yali Chen, Huang Huang, Charles Marshall, Junying Gao, Z. Cai, Ting-Yao Wu, G. Hu, Ming Xiao   +9 more
semanticscholar   +1 more source

Computational Fluid Dynamic Model Prediction of Enhanced Glymphatic Clearance in Response to Focused Ultrasound‐Mediated Blood‐Brain Barrier Opening

Advanced Science, EarlyView.
Focused ultrasound‐mediated blood‐brain barrier opening (FUS BBBO) for enhanced drug delivery also augments glymphatic clearance. A computational model of an arteriole‐venule pair in the brain offers insight into the underlying biotransport mechanisms responsible for this mass clearance effect.
Ryan A. Gladwell, Delaney G. Fisher, Joshua D. Wythe, Christopher B. Highley, John R. Lukens, Richard J. Price   +5 more
wiley   +1 more source

Differential Aquaporin Response to Distinct Effects of Two Zn Concentrations after Foliar Application in Pak Choi (Brassica rapa L.) Plants

Agronomy, 2020
Zinc (Zn) is considered an essential element with beneficial effects on plant cells; however, as a heavy metal, it may induce adverse effects on plants if its concentration exceeds a threshold.
Hamideh Fatemi, Chokri Zaghdoud, Pedro A. Nortes, Micaela Carvajal, Maria del Carmen Martínez-Ballesta   +4 more
doaj   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

Endogenous bioelectric currents promote differentiation of the mammalian lens [PDF]

, 2018
Acknowledgements We are grateful to Kevin S. Mackenzie in our imaging core facility. This work was supported by the University of Aberdeen (at which the majority of the experimental work was conducted).
Andley, Banno, Barrett, Bassnett, Bhat, Bhuyan, Blackiston, Bortner, Call, Cao, Chen, Chen, Chen, Eperon, Franco, Gwon, Gwon, Ibaraki, Kalous, Kolosova, Korlimbinis, Lampi, Lampi, Lee, Liu, Lois, Lovicu, Mathias, McCaig, Park, Patterson, Piatigorsky, Rajagopal, Robinson, Robinson, Sanderson, Sellitto, Shestopalov, Shestopalov, Sundelacruz, Sundelacruz, Sundelacruz, Thylefors, Ueda, Vaghefi, Wang, Wang, Wang, White, Wind, Wormstone, Yang, Zhao   +52 more
core   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, EarlyView.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

Hypoxia helps glioma to fight therapy [PDF]

, 2009
Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core   +1 more source

Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis

Frontiers in Chemistry, 2018
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers expected to increase 70% in the next two decades. The fact that current mainline treatments for cancer patients are accompanied by debilitating side effects prompts a ...
Michael L. De Ieso, A. Yool
semanticscholar   +1 more source

3D‐Printed Microfluidic Bioreactor Incorporating Electrospun Scaffolds for Creating an Enhanced Kidney Epithelial Cell Microenvironment

Journal of Applied Polymer Science, EarlyView.
Overview of cell seeding, attachment and scaffold insertion into bioreactor, with potential analyses listed after conditioning period. ABSTRACT Chronic kidney disease stands as a significant global health challenge, exacerbated by an ongoing scarcity of available organs for transplantation.
Todd P. Burton, Andrew P. Johnston, Alison McDonald, Rhiannon Grant, Anthony Callanan   +4 more
wiley   +1 more source