Results 31 to 40 of about 66,670 (341)

Discovery of Novel Human Aquaporin-1 Blockers [PDF]

ACS Chemical Biology, 2012
Human aquaporin-1 (hAQP1) is a water channel found in many tissues and potentially involved in several human pathologies. Selective inhibitors of hAQP1 are discussed as novel treatment opportunities for glaucoma, brain edema, inflammatory pain, and certain types of cancer.
Seeliger, Daniel, Zapater, Cinta, Krenc, Dawid, Haddoub, Rose, Flitsch, Sabine, Beitz, Eric, Cerdà, Joan, De Groot, Bert L.   +7 more
openaire   +5 more sources

AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma

Frontiers in Cell and Developmental Biology, 2021
The water channel aquaporin 1 (AQP1) has been implicated in tumor progression and metastasis. It is hypothesized that AQP1 expression can facilitate the transmembrane water transport leading to changes in cell structure that promote migration. Its impact
Zihe Huo, Zihe Huo, Mihai Lomora, Urs Kym, Urs Kym, Cornelia Palivan, Stefan G. Holland-Cunz, Stefan G. Holland-Cunz, Stephanie J. Gros, Stephanie J. Gros   +9 more
doaj   +1 more source

Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters [PDF]

, 2008
We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress,
C Zhu, DT Clarkson, DT Luu, E Zelazny, F Chaumont, GJ Cooper, GP Bienert, I Terashima, J Flexas, J Sakurai, J Takano, JF Ma, JY Jang, K Fetter, K Sato-Nara, LH Liu, M Katsuhara, M Katsuhara, M Katsuhara, M Katsuhara, Maki Katsuhara, N Uehlein, NL Nakhoul, P Kjellbom, R Aharon, R Vandeleur, S Suga, S Törnroth-Horsefield, SD Tyerman, TP Jahn, U Johanson, X Yang, YT Hanba, Yuko T. Hanba   +33 more
core   +1 more source

AQP1-Driven Migration Is Independent of Other Known Adverse Factors but Requires a Hypoxic Undifferentiated Cell Profile in Neuroblastoma

Children, 2021
Neuroblastoma is a biologically very heterogeneous tumor with its clinical manifestation ranging from spontaneous regression to highly aggressive metastatic disease.
Nicola Pini, Zihe Huo, Urs Kym, Stefan Holland-Cunz, Stephanie J. Gros   +4 more
doaj   +1 more source

Aquaporin-4 and brain edema. [PDF]

, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler, Alan S. Verkman, AS Verkman, AS Verkman, D Wenzel, DK Binder, DK Binder, DK Binder, DS Prough, GT Manley, H Wen, HJ Reulen, HK Kimelberg, I Klatzo, I Roberts, J Badaut, J Hu, J Li, J Li, JE Rash, JE Rash, K Oshio, KI Auguste, M Amiry-Moghaddam, M Amiry-Moghaddam, M Elkjaer, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, NR Saunders, O Bloch, P Agre, P Padmawar, PM Rodier, S Nielsen, S Saadoun, S Saadoun, T Ma   +38 more
core   +2 more sources

Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression

Scientific Reports, 2021
Exposure to arsenic, a ubiquitous metalloid on Earth, results in human cancers. Skin cancer is the most common arsenical cancers. Both autophagy and aquaporin pathway are known to promote carcinogenesis. However, the mechanisms by which arsenic regulates
Sebastian Yu, Ling-Hau Li, Chih-Hung Lee, Palaniraja Jeyakannu, Jeh-Jeng Wang, Chien-Hui Hong   +5 more
doaj   +1 more source

A proteomic and phosphoproteomic analysis of Oryza sativa plasma membrane and vacuolar membrane [PDF]

, 2008
Proteomic and phosphoproteomic analyses of rice shoot and root tonoplast-enriched and plasma membrane-enriched membrane fractions were carried out to look at tissue-specific expression, and to identify putative regulatory sites of membrane transport ...
Ahn, Alexandersson, Armengaud, Banuelos, Benschop, Brugiere, Carter, Chrispeels, Ducos, Dunkley, Endler, Gaxiola, Gierth, Jacquinod, Komatsu, Larsson, Loque, Lüttge, Ma, Maathuis, Maathuis, Marmagne, Morsomme, Niittyla, Nühse, Nühse, Paszkowski, Peltier, Pighin, Rentsch, Sancenon, Tanaka, Tornroth-Horsefield, Toyofuku, Vitart, Whiteman, Wintz, Wu, Yazaki   +38 more
core   +1 more source

Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. [PDF]

, 2013
Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Binder, Devin K, Jin, Byung-Ju, Verkman, AS, Zhang, Hua   +3 more
core   +2 more sources

The Fold of Human Aquaporin 1

Journal of Molecular Biology, 2000
The fold of human aquaporin 1 is determined from cryo-electron microscopic data at 4.5 A resolution. The monomeric structure consists of two transmembrane triple helices arranged around a pseudo-2-fold axis connected by a long flexible extracellular loop.
de Groot, B. L., Heymann, J. B., Engel, A., Mitsuoka, K., Fujiyoshi, Y., Grubmüller, H.   +5 more
openaire   +4 more sources

The physiological response of Populus tremula x alba leaves to the down-regulation of PIP1 aquaporin gene expression under no water stress. [PDF]

, 2013
In order to study the role of PIP1 aquaporins in leaf water and CO2 transport, several lines of PIP1-deficient transgenic Populus tremula x alba were generated using a reverse genetic approach. These transgenic lines displayed no visible developmental or
Secchi, Francesca, Zwieniecki, Maciej A
core   +3 more sources