Results 301 to 310 of about 69,793 (345)

Aquaporins, anti-aquaporin-4 autoantibodies and neuromyelitis optica

Clinica Chimica Acta, 2013
The classification, distribution and functions of the different molecules of aquaporins (AQPs), including aquaporins, aquaglyceroporins and superaquaporins are reviewed together with their potential diagnostic and therapeutic uses. We analyzed the pathogenic importance of anti-AQP4 autoantibodies in neuromyelitis optica and related syndromes, as well ...
Concepción, González, José M, González-Buitrago, Guillermo, Izquierdo   +2 more
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Aquaporin-4 and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
Alzheimer’s disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Canhong, Yang, Xiaomin, Huang, Xiaoyu, Huang, Hantao, Mai, Jie, Li, Tao, Jiang, Xiaofeng, Wang, Tianming, Lü   +7 more
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Neurological autoimmunity targeting aquaporin-4

Neuroscience, 2010
Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4). Immunological insights have propelled significant advances in understanding the clinical, radiologic and immunopathologic characteristics of ...
S R, Hinson, A, McKeon, V A, Lennon
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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
A S, Filippidis, M Y S, Kalani, H L, Rekate   +2 more
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Aquaporin-4 in hepatic encephalopathy

Metabolic Brain Disease, 2007
Brain edema is a critical component of hepatic encephalopathy (HE) associated with acute liver failure and such edema appears to be principally due to astrocyte swelling (cytotoxic edema). Ammonia is believed to represent a major factor responsible for astrocyte swelling, although the mechanisms by which ammonia causes such swelling are not completely ...
K V, Rama Rao, M D, Norenberg
openaire   +2 more sources

Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse

Journal of Neuroimmunology, 2012
Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH, Chu, ACY, Ho, PWL, Ho, JWM, Zhang, R, Kwan, JSC, Guo, VY   +6 more
openaire   +5 more sources

CNS aquaporin-4 autoimmunity in children

Neurology, 2008
In adult patients, autoantibodies targeting the water channel aquaporin-4 (AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with predilection for optic nerves and spinal cord (neuromyelitis optica [NMO]). Here we describe the neurologic, serologic, and radiographic findings associated with CNS AQP4 autoimmunity in ...
A, McKeon, V A, Lennon, T, Lotze, S, Tenenbaum, J M, Ness, M, Rensel, N L, Kuntz, J P, Fryer, H, Homburger, J, Hunter, B G, Weinshenker, K, Krecke, C F, Lucchinetti, S J, Pittock   +13 more
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Higher order structure of aquaporin-4

Neuroscience, 2010
Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM). However, FFEM cannot give information about the composition of OAPs of different sizes, and due to its technical complexity ...
NICCHIA, GRAZIA PAOLA, SVELTO, Maria, FRIGERI, Antonio, ROSSI A, MOLA MG, PISANI, FRANCESCO, STIGLIANO C, BASCO D, MASTROTOTARO M   +8 more
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Aquaporin-4 astrocytopathy in Baló’s disease

Acta Neuropathologica, 2010
Baló's concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO).
Takeshi, Matsuoka, Satoshi O, Suzuki, Toru, Iwaki, Takeshi, Tabira, Artemio T, Ordinario, Jun-ichi, Kira   +5 more
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Heterotetrameric Composition of Aquaporin-4 Water Channels

Biochemistry, 1999
Aquaporin (AQP) water channel proteins are tetrameric assemblies of individually active approximately 30 kDa subunits. AQP4 is the predominant water channel protein in brain, but immunoblotting of native tissues has previously yielded multiple poorly resolved bands.
Agre, Peter, Nielsen, S, Christensen, B. M., Neely, JD   +3 more
openaire   +2 more sources