Results 311 to 320 of about 69,793 (345)

Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

Multiple Sclerosis Journal, 2009
Background Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease.
T, Matsushita, N, Isobe, T, Matsuoka, N, Shi, Y, Kawano, X M, Wu, T, Yoshiura, Y, Nakao, T, Ishizu, J I, Kira   +9 more
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Aquaporin-4, homeostasis, and neurologic disease

Neurology, 2007
Aquaporins constitute a family of water channels that regulate the transport of water in essentially all organs, including the kidney, gastrointestinal tract, secretory glands, inner ear, nervous system, and muscle.1–3 Because of his seminal discovery of aquaporins as the long-sought water channels,1 Peter Agre of Johns Hopkins University was awarded ...
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Regulation of aquaporin-4 expression in astrocytes

Molecular Brain Research, 2001
Aquaporin-4 (AQP4), a mercury-insensitive water channel protein, is abundant in the central nervous system and is localized in astrocytes and ependymal cells. AQP4 is speculated to maintain the homeostasis of intracellular and extracellular water in the brain, but little is known about the mechanism of induction of its expression.
K, Yoneda, N, Yamamoto, K, Asai, K, Sobue, Y, Fujita, M, Fujita, M, Mase, K, Yamada, M, Nakanishi, T, Tada, Y, Miura, T, Kato   +11 more
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Inhibition of Aquaporin 4 by antiepileptic drugs

Bioorganic & Medicinal Chemistry, 2009
The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent ...
Vincent J, Huber, Mika, Tsujita, Ingrid L, Kwee, Tsutomu, Nakada   +3 more
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Clinical spectrum of CNS aquaporin-4 autoimmunity

Neurology, 2012
Traditionally, neuromyelitis optica (NMO) was known to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti-aquaporin-4 (AQP4) antibody for NMO enabled us to identify more diverse clinical manifestations. Here, we describe the demographic and clinical characteristics of patients who were anti-AQP4-antibody ...
S-H, Kim, W, Kim, X F, Li, I-J, Jung, H J, Kim   +4 more
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Aquaporin 4 deficiency modulates morphine pharmacological actions

Neuroscience Letters, 2008
Acute administration of opioids produces analgesia, while chronic administration induces tolerance and dependence. Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role in some pathophysiological processes in brain.
Ning, Wu, Xin-Qiang, Lu, Hai-Tao, Yan, Rui-Bin, Su, Ji-Fang, Wang, Yin, Liu, Gang, Hu, Jin, Li   +7 more
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Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin‐4

The FASEB Journal, 2004
ABSTRACT Aquaporin‐4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear. The purpose of this study was to assess the following in skeletal muscle: a) the expression of all cloned water cannels; b ...
FRIGERI, Antonio, NICCHIA, GRAZIA PAOLA, NICO, Beatrice, SVELTO, Maria, BALENA R   +4 more
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Renal expression and functions of aquaporin 1 and aquaporin 4 in cattle

Biotechnic & Histochemistry, 2013
Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine. Studies of renal AQPs have been performed in human, rodents, sheep, dogs and horses.
K, Altunbas, A, Cevik-Demirkan, O, Ozden-Akkaya, M S, Akosman   +3 more
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Regulation of water permeability through aquaporin-4

Neuroscience, 2010
Aquaporin-4 (AQP4) is a predominant water channel protein in mammalian brains that is distributed with the highest density in the perivascular and subpial astrocyte end-feet. AQP4 is a critical component of an integrated water and potassium homeostasis.
Y, Yukutake, M, Yasui
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Does Aquaporin-4–Seronegative Neuromyelitis Optica Exist?

JAMA Neurology, 2014
With the improvement in anti–aquaporin-4 (AQP4) assay sensitivity to near 90%,1 the concept of seronegative neuromyelitis optica (NMO) is being challenged. The widely accepted criteria forNMOproposed2 in 1999 and revised3 in 2006define NMO as a disease localized to the optic nerves and spinal cord, which is not multiple sclerosis (MS).
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