Results 91 to 100 of about 36,778 (260)

Cognitive impairment in neuromyelitis optica spectrum disorders

Неврология, нейропсихиатрия, психосоматика
Neuromyelitis optica spectrum disorders (NMOSD) are a group of immune-mediated inflammatory lesions of the central nervous system that primarily cause dysfunction and death of astrocytes, leading to secondary disruption of myelination.
E. A. Vekhina, D. S. Kasatkin, S. E. Korchevnyi, K. I. Bereznyak   +3 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

Investigation of Cytokines, Biochemical Parameters and Oxidative Stress Levels in Serum of Patients with Acute Pancreatitis

Genel Tıp Dergisi
Objective: This study aimed to find new serum biochemistry parameters, especially for the early identification of severe AP. In the study serum cytokine levels (TNF-A, IL-1, IL-6, IL-10, IL-21), biochemical parameters (Aquaporin-1, Hepcidine, Iron, Zinc,
Hamza Erdoğdu, Mehmet Bayraktar, Ahmet Uyanıkoğlu, Oruç Aslan, Nihayet Bayraktar, Ali Öztürk   +5 more
doaj   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Additional file 6: of Identification and characterization of aquaporin genes in Arachis duranensis and Arachis ipaensis genomes, the diploid progenitors of peanut

, 2019
Amino acid sequences of aquaporins from Arabidopsis thaliana, Glycine max and Oryza sativa used for BLASTp search. Sequence names of A. thaliana, G. max and O. sativa are preceded by the prefixes At, Gm and Os respectively. (DOCX 27 kb)
Shivaraj, S., Deshmukh, Rupesh, Sonah, Humira, BĂŠlanger, Richard   +3 more
openaire   +1 more source

IgG Subclass (IgG1‐4) and IgA Autoantibody Profiles Against Muscle‐Specific Kinase in a Greek Cohort

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Muscle‐specific kinase myasthenia gravis (MuSK‐MG) is an autoimmune neuromuscular disorder predominantly mediated by IgG4 autoantibodies disrupting MuSK signaling. The contribution of other isotypes remains incompletely defined. We characterized the serological profile of a Greek cohort of MuSK‐MG patients.
Sofia‐Natsοuko Gkotzamani, Maria Pechlivanidou, Francisca Faber, Cansu Elmas, Vasiliki Zouvelou, Elisabeth Chroni, Dimitrios Tzanetakos, Maria Kourouvani, Marlene Wolfsgruber, Ioannis Zaganas, Dimitra Kolovou, Michael Rentzos, Ariadne Daponte, Maria Chondrogiorgi, Spyridon Konitsiotis, Georgios Nicolaou, Stavroula Salakou, Sotirios Giannopoulos, Konstandinos Lazaridis, Georgios Tsivgoulis, Socrates Tzartos, Inga Koneczny, John S. Tzartos   +22 more
wiley   +1 more source

With Regard to the Expression Status of Sarcolemmal Aquaporin 4 in Human Muscular Dystrophies

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Human muscular dystrophies are inherited muscle‐wasting diseases caused by the various kinds of gene mutations. Among them, Duchenne muscular dystrophy (DMD) is a representative type. Before the discovery of the causative dystrophin gene of DMD, the fragile myofiber plasma membrane was thought to be the trigger of myofiber necrosis in DMD ...
Yoshihiro Wakayama, Takahiro Jimi
wiley   +1 more source

Dynamic characterization of pathological and functional deterioration in a mouse model of optic neuritis related to neuromyelitis optica spectrum disorder

Neural Regeneration Research
Neuromyelitis optica spectrum disorder–related optic neuritis involves various cellular responses to inflammation and degeneration. In most patients, the primary mechanism underlying neuromyelitis optica spectrum disorder–related optic neuritis is the ...
Xiayin Yang, Shi-Qi Yao, Henry Ho-Lung Chan, Shaoying Tan   +3 more
doaj   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source