Results 41 to 50 of about 38,099 (293)

Unique Regulation of AQP1 and AQP5 Expression by HIF-1 in Nucleus Pulposus Cells

Global Spine Journal, 2014
Introduction Aquaporins are a family of transmembrane water channels that aid in osmoregulation, a critical function in the proteoglycan-rich nucleus pulposus. Previous reports have demonstrated expression of aquaporins in the intervertebral disc.
S. Gogate, Z. Johnson, R. Day, A. Binch, D. Markova, N. Chiverton, A. Cole, M. Conner, I. Shapiro, C. L. Le Maitre, M. Risbud   +10 more
doaj   +1 more source

Inverting the selectivity of aquaporin 6: Gating versus direct electrostatic interaction [PDF]

Proceedings of the National Academy of Sciences, 2005
Specialized transmembrane proteins form channels that facilitate the transport of ions and other molecules across the membranes and thus play crucial role in many life processes. The understanding of these systems has increased enormously in recent years because of advances in structural and biochemical studies (e.g., refs. 1 and 2).
openaire   +2 more sources

Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes

, 2010
The continuous progress in the structural and functional characterization of aquaporins increasingly attracts attention to study their roles in certain mammalian diseases.
Volker Dötsch, Lian, Jiazhang, Kaldenhoff Ralf, Dötsch, Volker, Frank Bernhard, Xiangcheng Zhu, Cen, Peilin, Dötsch Volker, Lei Kai, Zhinan Xu, Xu, Zhinan, Peilin Cen, Kai Lei, Kai, Lei, Cen Peilin, Kaldenhoff, Ralf, Xu Zhinan, Zhu Xiangcheng, Ralf Kaldenhoff, Lian Jiazhang, Jiazhang Lian, Bernhard, Frank, Zhu, Xiangcheng, Bernhard Frank   +23 more
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Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

Frontiers in Genetics, 2021
Aquaporins (AQPs) are integral membrane proteins and found in all living organisms from bacteria to human. AQPs mainly involved in the transmembrane diffusion of water as well as various small solutes in a bidirectional manner are widely distributed in ...
Abul Kalam Azad, Topu Raihan, Jahed Ahmed, Jahed Ahmed, Al Hakim, Tanvir Hossain Emon, Parveen Afroz Chowdhury   +6 more
doaj   +1 more source

Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl

, 2012
It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining.
Lisa A Kirkwood, Kirkwood Lisa A., Rubenwolf, Peter C., Jennifer Southgate, Georgopoulos, Nikolaos T., Georgopoulos Nikolaos T., Rubenwolf Peter C., Kirkwood, Lisa A., Baker Simon C., Peter C Rubenwolf, Southgate, Jennifer, Southgate Jennifer, Baker, Simon C., Simon C Baker, Nikolaos T Georgopoulos   +14 more
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Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia

Fluids and Barriers of the CNS, 2023
Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chronic hypertriglyceridemia, we ...
Beáta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli, Zsófia Hoyk   +12 more
doaj   +1 more source

Neuromyelitis optica spectrum disorder: a pediatric case report

Medicine Science, 2017
Neuromyelitis optica spectrum disorder(NMOSD) is an autoimmune demyelinating disorder of the central nervous system that predominantly affects the optic nerves and the spinal cord.
Mujgan Arslan, Serdal Gungor, Betul Kilic, Kader Karli Oguz   +3 more
doaj   +1 more source

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1

American Journal of Physiology-Cell Physiology, 2008
We investigated mechanisms underlying GATA-6-mediated transcriptional activation of the alveolar epithelial type I cell-enriched gene aquaporin-5 (AQP5). GATA-6 expression increases in alveolar epithelial cells in primary culture, concurrent with upregulation of AQP5 and transition to a type I cell-like phenotype. Cotransfections in MLE-15 and NIH 3T3
Beiyun, Zhou, Tricia A, Francis, Hui, Yang, Wanru, Tseng, Qian, Zhong, Baruch, Frenkel, Edward E, Morrisey, David K, Ann, Parviz, Minoo, Edward D, Crandall, Zea, Borok   +10 more
openaire   +3 more sources

Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: the changes of aquaporin-4 and interleukin-6 [PDF]

Journal of Physiology and Biochemistry, 2015
The role of aquaporin-4 (AQP4) and interleukin-6 (IL-6) in the development of brain edema post-traumatic brain injury (TBI) has been indicated. The present study was designed to investigate the effect(s) of administration of progesterone (P) and/or estrogen (E) on brain water content, AQP4 expression, and IL-6 levels post-TBI.
Zahra, Soltani, Mohammad, Khaksari, Nader, Shahrokhi, Gholamabbas, Mohammadi, Behshad, Mofid, Ali, Vaziri, Sedigheh, Amiresmaili   +6 more
openaire   +2 more sources

Aquaporin-6 expression in rat gastrointestinal tract is upregulated by feeding

, 2010
Background: Some aquaporins have been identified and partially characterized in the gastrointestinal tract suggesting their involvement in fluid and small solutes movements. Here we studied the presence and localization of aquaporin-6 in some regions
MICHELETTI, PIERO, POLIMENI, MARIAROSA, GASTALDI, GIULIA, LAFORENZA, UMBERTO, TRITTO, SIMONA, Yasui Masato   +5 more
core   +1 more source