Results 31 to 40 of about 36,778 (260)

Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica [PDF]

Proceedings of the National Academy of Sciences, 2011
Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably play a pathogenic role. Here we show that a B-cell subpopulation, exhibiting the CD19 int CD27
Norio, Chihara, Toshimasa, Aranami, Wakiro, Sato, Yusei, Miyazaki, Sachiko, Miyake, Tomoko, Okamoto, Masafumi, Ogawa, Tatsushi, Toda, Takashi, Yamamura   +8 more
openaire   +2 more sources

Rhipicephalus (Boophilus) microplus aquaporin as an effective vaccine antigen to protect against cattle tick infestations

Parasites & Vectors, 2014
Background Vaccination as a control method against the cattle tick, Rhipicephalus (Boophilus) microplus has been practiced since the introduction of two products in the mid-1990s.
Felix D Guerrero, Renato Andreotti, Kylie G Bendele, Rodrigo C Cunha, Robert J Miller, Kathleen Yeater, Adalberto A Pérez de León   +6 more
doaj   +1 more source

The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma.

PLoS ONE, 2021
PurposeTo study aquaporin channel expression in astrocytes of the mouse optic nerve (ON) and the response to IOP elevation in mice lacking aquaporin 4 (AQP4 null).MethodsC57BL/6 (B6) and AQP4 null mice were exposed to bead-induced IOP elevation for 3 ...
Elizabeth Kimball, Julie Schaub, Sarah Quillen, Casey Keuthan, Mary Ellen Pease, Arina Korneva, Harry Quigley   +6 more
doaj   +1 more source

Role of Aquaporin-6 in Rat Parotid Secretory Granules

Journal of Oral Biosciences, 2011
Abstract Aquaporin-6 (AQP6) is a unique member of the family of AQP water channels and is involved in anion permeability. AQP6 was initially discovered in the cytoplasm of kidney cells as a kidney-specific AQP; however, subsequent studies revealed that the brain, inner ear, vestibular and intestines also express AQP6.
Matsuki-Fukushima, Miwako, Fujita-Yoshigaki, Junko, Murakami, Masataka, Katsumata-Kato, Osamu, Sugiya, Hiroshi   +4 more
openaire   +1 more source

Inverting the selectivity of aquaporin 6: Gating versus direct electrostatic interaction [PDF]

Proceedings of the National Academy of Sciences, 2005
Specialized transmembrane proteins form channels that facilitate the transport of ions and other molecules across the membranes and thus play crucial role in many life processes. The understanding of these systems has increased enormously in recent years because of advances in structural and biochemical studies (e.g., refs. 1 and 2).
openaire   +2 more sources

Unique Regulation of AQP1 and AQP5 Expression by HIF-1 in Nucleus Pulposus Cells

Global Spine Journal, 2014
Introduction Aquaporins are a family of transmembrane water channels that aid in osmoregulation, a critical function in the proteoglycan-rich nucleus pulposus. Previous reports have demonstrated expression of aquaporins in the intervertebral disc.
S. Gogate, Z. Johnson, R. Day, A. Binch, D. Markova, N. Chiverton, A. Cole, M. Conner, I. Shapiro, C. L. Le Maitre, M. Risbud   +10 more
doaj   +1 more source

Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

Frontiers in Genetics, 2021
Aquaporins (AQPs) are integral membrane proteins and found in all living organisms from bacteria to human. AQPs mainly involved in the transmembrane diffusion of water as well as various small solutes in a bidirectional manner are widely distributed in ...
Abul Kalam Azad, Topu Raihan, Jahed Ahmed, Jahed Ahmed, Al Hakim, Tanvir Hossain Emon, Parveen Afroz Chowdhury   +6 more
doaj   +1 more source

Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia

Fluids and Barriers of the CNS, 2023
Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chronic hypertriglyceridemia, we ...
Beáta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli, Zsófia Hoyk   +12 more
doaj   +1 more source

Neuromyelitis optica spectrum disorder: a pediatric case report

Medicine Science, 2017
Neuromyelitis optica spectrum disorder(NMOSD) is an autoimmune demyelinating disorder of the central nervous system that predominantly affects the optic nerves and the spinal cord.
Mujgan Arslan, Serdal Gungor, Betul Kilic, Kader Karli Oguz   +3 more
doaj   +1 more source

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1

American Journal of Physiology-Cell Physiology, 2008
We investigated mechanisms underlying GATA-6-mediated transcriptional activation of the alveolar epithelial type I cell-enriched gene aquaporin-5 (AQP5). GATA-6 expression increases in alveolar epithelial cells in primary culture, concurrent with upregulation of AQP5 and transition to a type I cell-like phenotype. Cotransfections in MLE-15 and NIH 3T3
Beiyun, Zhou, Tricia A, Francis, Hui, Yang, Wanru, Tseng, Qian, Zhong, Baruch, Frenkel, Edward E, Morrisey, David K, Ann, Parviz, Minoo, Edward D, Crandall, Zea, Borok   +10 more
openaire   +3 more sources