Results 41 to 50 of about 1,271,022 (291)

Paper-Based Microfluidic Platforms for Understanding the Role of Exosomes in the Pathogenesis of Major Blindness-Threatening Diseases

open access: yesNanomaterials, 2018
Emerging roles of exosomes in the pathogenesis of major blindness-threatening diseases, such as age-related macular degeneration, glaucoma, and corneal dystrophy, were discovered by aqueous humor analysis.
Min-Yen Hsu   +8 more
doaj   +1 more source

Aqueous Humor Markers in Retinoblastoma, a Review

open access: yesTranslational Vision Science & Technology, 2019
Purpose Retinoblastoma (Rb) is the most common primary intraocular cancer in children. Unlike with most solid tumors, direct biopsy is contraindicated due to risk of tumor dissemination.
Benjamin K. Ghiam   +2 more
semanticscholar   +1 more source

Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma.

open access: yesInvestigative Ophthalmology and Visual Science, 2019
Purpose To investigate whether we can identify different patterns of inflammation in the aqueous humor of a uveal melanoma (UM)-containing eye, and whether these are related to prognosis.
A. P. Wierenga   +11 more
semanticscholar   +1 more source

The Effects of Netarsudil Ophthalmic Solution on Aqueous Humor Dynamics in a Randomized Study in Humans

open access: yesJournal of Ocular Pharmacology and Therapeutics, 2018
Purpose: Netarsudil, an inhibitor of Rho kinase and a norepinephrine transporter, has been shown to lower elevated intraocular pressure (IOP) in controlled studies of patients with open-angle glaucoma and ocular hypertension, and in healthy volunteers ...
A. Kazemi   +5 more
semanticscholar   +1 more source

Age-related changes of vitamin C levels in aqueous humour [PDF]

open access: yesVojnosanitetski Pregled, 2015
Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to
Čanadananović Vladimir   +4 more
doaj   +1 more source

Aqueous Humor is Superior to Blood as a Liquid Biopsy for Retinoblastoma

open access: yesOphthalmology (Rochester, Minn.), 2019
Whole genome sequencing was performed on 20 matched blood and aqueous samples; tumor-associated chromosomal changes were found in 0/20 blood vs. 11/20 aqueous samples along with shorter DNA fragments. Thus, aqueous is superior to blood as a liquid biopsy
Jesse L. Berry   +6 more
semanticscholar   +1 more source

NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression

open access: yesCell Reports, 2021
Summary: Anterior segment dysgenesis is often associated with cornea diseases, cataracts, and glaucoma. In the anterior segment, the ciliary body (CB) containing inner and outer ciliary epithelia (ICE and OCE) secretes aqueous humor that maintains ...
Ji Pang   +17 more
doaj   +1 more source

Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys

open access: yesJournal of Ocular Pharmacology and Therapeutics, 2018
Purpose: To investigate the mechanism of the intraocular pressure (IOP)-lowering effect of a novel selective prostaglandin E2 receptor 2 (EP2) receptor agonist, omidenepag isopropyl (OMDI).
M. Fuwa   +10 more
semanticscholar   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

open access: yesAdvanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka   +2 more
wiley   +1 more source

Nocturnal Intraocular Pressure Monitoring With a Soft Contact Lens Sensor for Glaucoma Management

open access: yesAdvanced Materials, EarlyView.
A soft contact lens sensor enables continuous, noninvasive monitoring of nocturnal intraocular pressure (IOP) under closed‐eye sleep conditions. By integrating a highly compliant inductive–capacitive circuit onto a commercial lens, the device achieves record sensitivity and stable performance.
Yumin Dai   +19 more
wiley   +1 more source

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