Results 11 to 20 of about 7,402,456 (286)

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter, Anastasia C. Hepburn, AS Goldstein, AT Collins, AT Collins, C Cai, C Lin, CD Chen, CJ Shepherd, Claudia A. Ryan-Munden, CM van der Loos, Craig N. Robson, D Corbeil, DA Lawson, Deepali Pal, DJ Vander Griend, DM Owens, DT Ross, G Attard, G Buchanan, GD Richardson, GR Cunha, H Bonkhoff, H Bonkhoff, Hing Y. Leung, IV Litvinov, J Perez-Losada, J Yu, JA Kemppainen, JK Blackwood, Kelly Coffey, KG Leong, KM Bae, L Patrawala, Laura Wilson, LE Lamb, MC Haffner, N Platet, NT Gaisa, R Heer, R Heer, Rakesh Heer, S Kolli, S Mousses, SO Lee, Stuart C. Williamson, VK Rajasekhar, X Wang, Yao Liang Tang   +48 more
core   +10 more sources

Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. [PDF]

, 2016
Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).
Hoang, David T., Iczkowski, Kenneth A., Kilari, Deepak, Nevalainen, Marja T., See, William   +4 more
core   +2 more sources

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]

, 2016
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Duan, Zhijian, Evans, Christopher P, Evans, Ronald M, Gao, Allen C, Kung, Hsing-Jien, Lam, Kit S, Louie, Maggie C, Wang, Junjian, Xiang, Qiuping, Xu, Jianzhen, Xu, Yong, Xue, Xiaoqian, Yang, Joy C, Zhang, Yan, Zou, June X   +17 more
core   +2 more sources

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]

, 2019
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J., Merry, Diane E., Pluciennik, Anna   +2 more
core   +3 more sources

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function [PDF]

, 2002
This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Chang, Chawnshang, Fu, Maofu, Fuqua, Suzanne A W, Hay, Ronald Thomas, Hopp, Torsten, Jaffray, E, Janne, OA, Palvimo, Jorma J, Pestell, RG0, Sakamaki, Toshiyuki, Wang, Chenguang, Wang, Jian, Yeung, YG, Zhang, Xueping   +13 more
core   +1 more source

Investigating genetic predisposition to premature decline in ovarian reserve

Акушерство, гинекология и репродукция, 2022
Introduction. Normal ovarian reserve (OR) determining the ovarian response to follicle development containing fully-featured oocytes is an important factor in pregnancy, including assisted reproductive technology (ART) programs.
E. V. Kudryavtseva, N. V. Kurbatova, V. V. Кovalev, D. K. Islamidi   +3 more
doaj   +1 more source

Strong 3p -T1u Hybridization in Ar@C60 [PDF]

, 2010
Multilayers of fullerenes with and without endohedral Ar units, C60 and Ar@C60, were investigated by photoemission and density functional theory. The stoichiometry and the endohedral nature of Ar is checked by x-ray photoelectron spectroscopy and x-ray ...
Dragoe, N., Greber, T., Ito, S., Morscher, M., Seitsonen, A., Takagi, H.   +5 more
core   +1 more source

Are Children “Normal”? [PDF]

Review of Economics and Statistics, 2008
We examine Becker's (1960) contention that children are "normal." For the cross section of non-Hispanic white married couples in the U.S., we show that when we restrict comparisons to similarly-educated women living in similarly-expensive locations, completed fertility is positively correlated with the husband's income.
Black, Dan A., Kolesnikova, Natalia, Sanders, Seth G., Taylor, Lowell J.   +3 more
openaire   +9 more sources

Idioms are Oblivious, Arrows are Meticulous, Monads are Promiscuous [PDF]

Electronic Notes in Theoretical Computer Science, 2011
AbstractWe revisit the connection between three notions of computation: Moggiʼs monads, Hughesʼs arrows and McBride and Patersonʼs idioms (also called applicative functors). We show that idioms are equivalent to arrows that satisfy the type isomorphism A↝B≃1↝(A→B) and that monads are equivalent to arrows that satisfy the type isomorphism A↝B≃A→(1↝B ...
Lindley, Sam, Wadler, Philip, Yallop, Jeremy   +2 more
openaire   +3 more sources

Evolution of active region outflows throughout an active region lifetime [PDF]

, 2016
We have shown previously that SOHO/UVCS data allow us to detect active region (AR) outflows at coronal altitudes higher than those reached by other instrumentation. These outflows are thought to be a component of the slow solar wind.
Poletto, G., Zangrilli, L.
core   +2 more sources