Results 71 to 80 of about 1,498,337 (287)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Integrative Bioinformatics, 2019 Gene expression studies revealed a large degree of variability in gene expression patterns particularly in tissues even in genetically identical individuals. It helps to reveal the components majorly fluctuating during the disease condition.
Asati Nimisha +3 more
doaj +1 more source
Água e ar em uma cidade higiênica, asséptica, inodora
Revista Brasileira de História da Ciência, 2018 Este artigo busca problematizar aspectos que atravessaram a reordenação de espaços urbanos na viragem do século XIX para o XX. Tendo Belo Horizonte como referência, elenca questões que estiveram presentes nas discussões a respeito da construção de uma ...
Verona Campos Segantini
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Ar - atividade 4: O ar exerce pressão
, 2011 Guia de experimentos que permite constatar a pressão exercida pelo ar. Dessa forma, nota-se que a pressão do ar é a força exercida pelo mesmo a qual está diretamente relacionada ao seu pesoEducação Infantil::Natureza e ...
Passos, Evandro Ferreira
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Special Section Preface: Informative Models and Systems for Virtual Museums
Virtual Archaeology Review, 2019 Special Section ...
R. Brumana, G. Tucci, J.L. Lerma
doaj +1 more source
, 2018 A. Genes most highly associated (bivariate cutoff 1.0E-07) with AR expression across the TCGA dataset were used to determined novel gene expression signatures associated with AR tumor status. Distinct subgroups of genes with shared expression trends were
Shweta Tripathi (591806) +10 more
core +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source