Results 81 to 90 of about 8,277,314 (334)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Mechanisms underlying androgen receptor (AR) splice variant 7 (AR-V7) oncogenic function at the genomic level remain poorly defined. Studies here found that AR-V7 cistromes are cell-context–dependent in castration-resistant prostate cancer ...
Zhong Chen, Dayong Wu, J. Thomas-Ahner, Changxue Lu, P. Zhao, Qingfu Zhang, Connor M. Geraghty, P. Yan, W. Hankey, Benjamin D. Sunkel, Xiaolong Cheng, E. Antonarakis, Qi-En Wang, Zhihua Liu, T. Huang, V. Jin, S. Clinton, Jun Luo, Jiaoti Huang, Qianben Wang   +19 more
semanticscholar   +1 more source

Evolution of Anemone AR NOAA 10798 and the Related Geo-Effective Flares and CMEs

, 2008
We present a detailed examination of the features of the Active Region (AR) NOAA 10798. This AR generated coronal mass ejections (CMEs) that caused a large geomagnetic storm on 24 August 2005 with the minimum Dst index of -216 nT.
Alexander, Asai, Asai, Ayumi Asai, Bruzek, Delaboudiniére, Domingo, Forsyth, Gopalswamy, Gopalswamy, Gopalswamy, Gopalswamy, Gopalswamy, Gosling, Hale, Ishii, Kataoka, Kazunari Shibata, Ken'ichi Fujiki, Kojima, Kokubun, Kundu, Kurokawa, Lepping, Liu, Liu, Low, López Fuentes, Manoharan, Martin, Matsumoto, Mitsuo Oka, Mukai, Munro, Nagashima, Nat Gopalswamy, Rust, Ryuho Kataoka, Saito, Saito, Scherrer, Sheeley, Sheeley, Sheeley, Shibata, Shibata, Shibata, Takahashi, Takako T. Ishii, Terasawa, Tian, Tokumaru, Tokumaru, Tokumaru, Tousey, Verma, Vourlidas, Wang, Wang, Yashiro, Yokoyama, Yokoyama, Young, Zhang   +63 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

AR moulded-objects performing Giuseppe Verdi's 200th birthday

Archeomatica, 2014
"Muri e Divisioni" è una mostra collettiva di arte contemporanea. Una call for artists è stata organizzata da Accademia delle Arti di Macerata, un'organizzazione locale no-profit composta da 40 artisti, per raccogliere opere adeguate per la mostra.
Giuliana Guazzaroni, Mirco Compagno
doaj  

The Effect of a Reduced-Calorie Diet on alpha-2 Adrenergic Receptor Responsiveness in Abdominal Adipose Tissue in Obese Men During Exercise [PDF]

, 2008
There is at present an imperfect understanding of the effect of diet on availability of inhibitory receptors in fat cells during exercise among obese men. *Objective:* The purpose of this study was to determine whether diet results in
David Turbow, Edith Neumann, Joseph O. Schmelz, Roy R. Estrada   +3 more
core   +1 more source

Geometrical aspects of quantum walks on random two-dimensional structures

, 2013
We study the transport properties of continuous-time quantum walks (CTQW) over finite two-dimensional structures with a given number of randomly placed bonds and with different aspect ratios (AR).
Anishchenko, Anastasiia, Blumen, Alexander, Muelken, Oliver   +2 more
core   +1 more source

Higgs signals and hard photons at the Next Linear Collider: the $ZZ$-fusion channel in the Standard Model [PDF]

, 1996
In this paper, we extend the analyses carried out in a previous article for $WW$-fusion to the case of Higgs production via $ZZ$-fusion within the Standard Model at the Next Linear Collider, in presence of electromagnetic radiation due real photon ...
Altarelli G, Bardin D, Barklow T, Bjorken J D, Cahn R N, Ioffe B L, KEK, Kniehl B, Kuraev E A, Moretti S, Nicrosini O, Orawa R, Settles R, Stefano Moretti, Zerwas P M   +14 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Arte e tecnica materiale nell’Encyclopédie [PDF]

S&F_scienzaefilosofia.it, 2018
Art and material technology in the Encyclopédie The Diderot’s article Art of the Encyclopédie is not only an essay about the classic division between liberal and mechanical arts but also a new way of advocating the second ones.
Cosenza, Mario
doaj