Results 211 to 220 of about 116,348 (354)

Optimization of MALDI Matrices and Their Preparation for the MALDI‐TOF MS Analysis of Oligonucleotides

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue 15, 15 August 2025.
ABSTRACT Rationale The reproducibility of the analysis of oligonucleotides using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) remains a significant challenge. This is mainly attributed to factors such as the choice and application of the matrix, as well as the inhomogeneity of the sample spots.
Susanne Dietrich   +3 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, Volume 599, Issue 15, Page 2190-2200, August 2025.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Photocatalytic syntheses and evaluation of biological activities of rare disaccharides, 3-O-α-D-glucopyranosyl-D-arabinose. [PDF]

open access: yesSci Rep
Usuki S   +9 more
europepmc   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

open access: yesAdvanced Science, Volume 12, Issue 29, August 7, 2025.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu   +12 more
wiley   +1 more source

Systematic synthesis of rare sugars and stereospecific conversion via photocatalysis. [PDF]

open access: yesSci Rep
Patil PB   +7 more
europepmc   +1 more source

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