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Association between polymorphisms of arachidonate 12-lipoxygenase (
Behavioral and Brain Functions, 2010 Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia.
Park Jin +4 more
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Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio) [PDF]
The Journal of Reproduction and DevelopmentImmature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI +4 more
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Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma [PDF]
Communications BiologyApproximately 10% of pregnant women worldwide suffer from asthma, significantly increasing risks like preterm birth, low birth weight, and gestational hypertension. Current diagnostic methods are limited in early detection, underscoring the need for more
Liyuan Wang +13 more
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Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women
Frontiers in Oncology, 2021 COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined ...
Jennifer M. Mongiovi +10 more
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The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients.
Jessica Bonucci +5 more
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Research, 2023 Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong +16 more
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Nature Communications, 2023 Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we
Jinjie Duan +9 more
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ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens, with data on DNA, on the protein encoded, and where the gene is implicated.
A Erdog, S Banerjee
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Albumin redirects platelet eicosanoid metabolism toward 12(S)-hydroxyeicosatetraenoic acid.
Journal of Lipid Research, 1989 Albumin is a major determinant of eicosanoid formation, affecting autacoids important in cell-cell interactions. We delineated three mechanisms by which albumin controlled platelet eicosanoid formation: 1) Albumin diverted free arachidonate toward 12 ...
M J Broekman, A M Eiroa, A J Marcus
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Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities
Journal of Lipid Research, 1994 Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15 ...
H Kühn, J Belkner, H Suzuki, S Yamamoto
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