Results 1 to 10 of about 17,310 (176)

Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population [PDF]

Behavioral and Brain Functions, 2010
Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia.
Park Jin, Kim Hak-Jae, Kim Tae, Kim Jong, Chung Joo-Ho   +4 more
doaj   +3 more sources

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. [PDF]

J Biol Chem, 2020
The incidence of pancreatic cancer increases with age, suggesting that chronological aging is a significant risk factor for this disease. Fibroblasts are the major nonmalignant cell type in the stroma of human pancreatic ductal adenocarcinoma (PDAC).
Sarsour EH, Son JM, Kalen AL, Xiao W, Du J, Alexander MS, O'Leary BR, Cullen JJ, Goswami PC.   +8 more
europepmc   +2 more sources

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio) [PDF]

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +2 more sources

Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells. [PDF]

Journal of Histochemistry & Cytochemistry, 1995
Arachidonate 12-lipoxygenase is an enzyme that oxygenates the 12 position of arachidonic acid to produce its 12-hydroperoxy derivative. We were interested in the tissue distribution and subcellular localization of the platelet-type 12-lipoxygenase, which is distinguished from the leukocyte type by several criteria.
M, Nakamura, N, Ueda, K, Kishimoto, T, Yoshimoto, S, Yamamoto, K, Ishimura   +5 more
openaire   +3 more sources

Immunohistochemical study of arachidonate 12-lipoxygenase in porcine tissues. [PDF]

Journal of Histochemistry & Cytochemistry, 1989
12-Lipoxygenase oxygenates the 12 position of arachidonic acid and produces its 12-hydroperoxy derivative. The enzyme is found in greatest amounts in porcine leukocytes and is distributed widely in various other tissues. An anti-12-lipoxygenase antibody was raised in rabbits with the immunoaffinity-purified enzyme as an antigen and was used in ...
T, Maruyama, N, Ueda, T, Yoshimoto, S, Yamamoto, N, Komatsu, K, Watanabe   +5 more
openaire   +3 more sources

Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis [PDF]

Nature Communications
Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with
Jiayan Jin, Zeyu Zheng, Jiaxuan Gu, Qibin Zhang, Zhikun Xu, Zhenhua Feng, Siyue Tao, Shumin He, Jiao Cheng, Jian Wang, Hou-Feng Zheng, Shishi Li, Fengdong Zhao, Jian Chen   +13 more
doaj   +2 more sources

Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma [PDF]

Communications Biology
Approximately 10% of pregnant women worldwide suffer from asthma, significantly increasing risks like preterm birth, low birth weight, and gestational hypertension. Current diagnostic methods are limited in early detection, underscoring the need for more
Liyuan Wang, Xuan Wang, Wenying Wang, Zhengpeng Sun, Huafeng Fang, Chongjun Qi, Wei Lin, Lili Lin, Tong Xie, Cunsi Shen, Chen Shi, Jianya Xu, Feng Ge, Jinjun Shan   +13 more
doaj   +2 more sources

Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

Journal of Biological Chemistry, 1992
Arachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. With the aid of cDNA probes for the enzyme, we isolated overlapping lambda clones encompassing the human 12-lipoxygenase gene and flanking regions from a human genomic library.
T, Yoshimoto, T, Arakawa, T, Hada, S, Yamamoto, E, Takahashi   +4 more
openaire   +3 more sources

Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells. [PDF]

Int J Oncol, 2011
Yin B, Yang Y, Zhao Z, Zeng Y, Mooney SM, Li M, Xu X, Song Y, Wu B, Yang Z.   +9 more
europepmc   +2 more sources

The transcriptional regulation of human arachidonate 12‐lipoxygenase gene by NFκB/Rel [PDF]

FEBS Letters, 1995
As examined by the luciferase assay, a negative regulatory region including the NFκB motif was found in the 5′‐flanking region of the 12‐lipoxygenase gene in human erythroleukemia cells. The negative control was abolished by a site‐specific mutation of the NFκB motif. Probes including the NFκB region gave positive bands upon a gel‐shift assay.
Arakawa, Toshiya, Nakamura, Michihiro, Yoshimoto, Tanihiro, Yamamoto, Shozo   +3 more
openaire   +3 more sources