Results 1 to 10 of about 15,538 (196)

Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population [PDF]

Behavioral and Brain Functions, 2010
Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia.
Park Jin, Kim Hak-Jae, Kim Tae, Kim Jong, Chung Joo-Ho   +4 more
doaj   +5 more sources

ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens, with data on DNA, on the protein encoded, and where the gene is implicated.
A Erdog, S Banerjee
exaly   +2 more sources

Chilling injury mechanism in the immature oocytes of zebrafish (Danio rerio) [PDF]

The Journal of Reproduction and Development
Immature zebrafish oocytes are sensitive to chilling, and their survival is markedly reduced by exposure to 0°C. In the present study, we investigated the involvement of cold-sensitive channels and lipid mediators in chilling injury in immature zebrafish ...
Yanuar ACHADRI, Shino SONODA, Saki OKUBO, Kazutsugu MATSUKAWA, Keisuke EDASHIGE   +4 more
doaj   +2 more sources

Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma [PDF]

Communications Biology
Approximately 10% of pregnant women worldwide suffer from asthma, significantly increasing risks like preterm birth, low birth weight, and gestational hypertension. Current diagnostic methods are limited in early detection, underscoring the need for more
Liyuan Wang, Xuan Wang, Wenying Wang, Zhengpeng Sun, Huafeng Fang, Chongjun Qi, Wei Lin, Lili Lin, Tong Xie, Cunsi Shen, Chen Shi, Jianya Xu, Feng Ge, Jinjun Shan   +13 more
doaj   +2 more sources

Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women

Frontiers in Oncology, 2021
COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined ...
Jennifer M. Mongiovi, Jennifer M. Mongiovi, Chi-Chen Hong, Gary R. Zirpoli, Thaer Khoury, Angela R. Omilian, Bo Qin, Elisa V. Bandera, Song Yao, Christine B. Ambrosone, Zhihong Gong   +10 more
doaj   +1 more source

The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients.
Jessica Bonucci, Alfredo Gragnani, Marcelo Moraes Trincado, Victor Vincentin, Silvana Aparecida Alves Correa, Lydia Masako Ferreira   +5 more
doaj   +1 more source

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

Research, 2023
Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, Yongle Chen, Xiaobo Cai, Yi Zhang, Linhua Jiang, Wei Yang, Peilin Yu, Hui Lin   +16 more
doaj   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
core   +4 more sources

Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity

Nature Communications, 2023
Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we
Jinjie Duan, Wenhui Dong, Guangyan Wang, Wenjing Xiu, Guangyin Pu, Jingwen Xu, Chenji Ye, Xu Zhang, Yi Zhu, Chunjiong Wang   +9 more
doaj   +1 more source

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source