Modulation of guanosine triphosphatase activity of G proteins by arachidonic acid in rat Leydig cell membranes [PDF]
, 2000 Previous results from our group have indicated that arachidonic acid decrease cAMP production through a modification of heterotrimericGproteins.\ud In the present study, we have characterized the high affinity GTPase activity present in Leydig cell ...
Colás Escudero, Begoña +4 more
core +3 more sources
The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier [PDF]
, 2014 This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning.
Brash, Alan R. +4 more
core +1 more source
Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.
Journal of Biological Chemistry, 1992 The gene encoding arachidonate 12-lipoxygenase was cloned from a porcine EMBL3 genomic library using a cDNA probe of the enzyme, and its nucleotide sequence was determined. The gene consists of 14 exons with 13 introns, and spans approximately 8 kilobases.
T, Arakawa +4 more
openaire +2 more sources
Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11
BMC Complementary Medicine and TherapiesBackground Luteolin (3,4,5,7-tetrahydroxy flavone) is reported to strongly protect from acute carbon tetrachloride (CCl4) -induced liver injury or fibrosis. Ferroptosis can be induced by hepatic injury, and contributes to liver fibrosis development.
Zhiqiang Han +6 more
doaj +1 more source
The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage [PDF]
, 2001 OBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances ...
Arthur, AS +6 more
core +1 more source
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways [PDF]
, 2009 Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of ...
Cavaleiro, José +6 more
core +2 more sources
DNA methylation and stroke prognosis: an epigenome-wide association study
Clinical EpigeneticsBackground and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetics, including DNA ...
Joan Jiménez-Balado +17 more
doaj +1 more source
Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis [PDF]
, 2017 An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process.
Bray, Michael A. +5 more
core
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. [PDF]
J Biol Chem, 2020 Sarsour EH +8 more
europepmc +1 more source
BMC GastroenterologyBackground Irisin, a recently identified protein that is released during exercise and promotes the transformation of white adipocytes into brown adipocytes.
Zhenyu Li, Beile Wang, Xinyu Li
doaj +1 more source