Results 81 to 90 of about 15,557 (213)

The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
The interplay between ferroptosis and the tumor immune microenvironment significantly influences the outcome of cancer immunotherapy. Inducing ferroptosis in tumor cells and immunosuppressive cells, while preventing ferroptosis in effector immune cells, emerges as a promising strategy to enhance the efficacy of immunotherapy. This review highlights the
Fenfen Zhan, Yanyan Hu, Xiang Jiang, Zejun Fang   +3 more
wiley   +1 more source

Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis

Hereditas
Background Gastric cancer (GC) remains a significant global health challenge due to its high mortality and frequent resistance to chemotherapy drugs like cisplatin (DDP). Carnosic acid (CA), a phenolic diterpene, exhibits potential anti-cancer properties.
Li Zhou, Bin Xu, Baojian Li
doaj   +1 more source

Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

Journal of Biological Chemistry, 1992
Arachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. With the aid of cDNA probes for the enzyme, we isolated overlapping lambda clones encompassing the human 12-lipoxygenase gene and flanking regions from a human genomic library.
T, Yoshimoto, T, Arakawa, T, Hada, S, Yamamoto, E, Takahashi   +4 more
openaire   +2 more sources

Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

Efficacy and Mechanism Evaluation, 2015
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg   +13 more
doaj   +1 more source

Fatty acids in veterinary medicine and research [PDF]

, 2017
Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the body ...
Mostyn, Alison, Rutland, Catrin S., Simpson, Siobhan   +2 more
core   +2 more sources

Targeting of the Alox12-12-HETE in Blast Crisis Chronic Myeloid Leukemia Inhibits Leukemia Stem/Progenitor Cell Function

Cancer Management and Research, 2020
Si Gao,1,2,* Jialin Hu,3,* Yong Li4 1Department of Haematology and Rheumatology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2The Central ...
Gao S, Hu J, Li Y
doaj  

Role of cyclooxygenae-2 and 5-lypoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy:implications for pharmacogenomics [PDF]

, 2010
Alzheimer's disease (AD) is a neurodegenerative disorder clinically characterized by cognitive deficit with progressive worsening of memory. Recent data indicate that neurons, as well as other brain cells, can express enzymes such as cyclooxygenases ...
CANDORE, Giuseppina, CARUSO, Calogero, Chiappelli,M, COLONNA ROMANO, Giuseppina, Licastro,F, LIO, Domenico, LISTI', Florinda   +6 more
core   +1 more source

Platelet-type Arachidonate 12-Lipoxygenase in Mouse Gastrointestinal Tract.

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1998
12-Lipoxygenase enzyme oxygenates the position 12 of arachidonic acid, and produces 12S-hydroperoxy-arachidonic acid. When mouse gastrointestinal tract was immunostained with an antiserum against human platelet 12-lipoxygenase and examined by light microscopy, positively-stained cells were found in the epithelium of stomach and small and large ...
Michihiro Nakamura, Shozo Yamamoto, Kazunori Ishimura   +2 more
openaire   +2 more sources

Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture

Journal of Inflammation Research, 2015
Nicole J Kubat,1 John Moffett,2 Linley M Fray2 1Nicole Kubat Consulting, Pasadena, CA, USA; 2Life Science Department, Regenesis Biomedical, Inc., Scottsdale, AZ, USA Abstract: Inflammation is a complex process involving distinct but overlapping ...
Kubat NJ, Moffett J, Fray LM
doaj  

Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis

Frontiers in Immunology
Visceral leishmaniasis (VL), the most severe form of leishmaniasis, remains a significant public health concern that cannot be overlooked in underdeveloped regions.
Dongmei Yuan, Hanxiao Qin, Zeying Yu
doaj   +1 more source