Results 111 to 120 of about 10,969 (168)

Design, synthesis, characterization, biological investigation and docking studies of newly synthesized sulphonyl hydrazide and their derivatives. [PDF]

Sci Rep
Rahman M, Zafar R, Jan MS, Darwish HW, Khattak H, Aschner M, Daglia M, Khan H.   +7 more
europepmc   +1 more source

Celastrol suppresses bone destruction in rheumatoid arthritis by inhibiting ALOX5 expression in macrophages via the NF-κB pathway. [PDF]

Sci Rep
Chen Y, Wang Z, Chen Y, Liu X, Liu L, Tu Z, Tao Q, Xu Y.   +7 more
europepmc   +1 more source

Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke. [PDF]

Toxicol Rep
Boonmag S, Reiter RJ, Govitrapong P.
europepmc   +1 more source

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation. [PDF]

Front Pharmacol
Gao S, Wang H.
europepmc   +1 more source

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Arachidonate 12-lipoxygenases

Prostaglandins & Other Lipid Mediators, 2002
Arachidonate 12-lipoxygenase introduces a molecular oxygen at carbon 12 of arachidonic acid to generate a 12-hydroperoxy derivative. The enzymes generate 12-hydroperoxy derivatives with either S- or R-configurations. There are three isoforms of 12S-lipoxygenases named after the cells where they were first identified; platelet, leukocyte and epidermis ...
Tanihiro, Yoshimoto, Yoshitaka, Takahashi   +1 more
openaire   +2 more sources

Arachidonate 12-Lipoxygenase Isozymes

1999
A lipoxygenase is an enzyme which incorporates one molecule of oxygen into arachidonic acid or other polyunsaturated fatty acids producing hydroperoxy acids with a conjugated diene system. Enzymes oxygenating at the positions 5, 8, 12 and 15 of arachidonic acid and producing the corresponding hydroperoxy eicosatetraenoic acid (HpETE) have been isolated
S, Yamamoto, H, Suzuki, M, Nakamura, K, Ishimura   +3 more
openaire   +2 more sources

Mammalian Arachidonate 12-Lipoxygenases

1997
Since arachidonate 12-lipoxygenase was earlier found in platelets as the first mammalian lipoxygenase, the enzyme has been found in a variety of tissues of a number of animal species. On the basis of our studies in the last decade, we have demonstrated that there are two isoforms of 12-lipoxygenase (1).
S, Yamamoto, Y, Takahashi, T, Hada, H, Hagiya, H, Suzuki, G R, Reddy, N, Ueda, T, Arakawa, M, Nakamura, S, Matsuda, Y, Taketani, T, Yoshimoto, T, Azekawa, Y, Morita, K, Ishimura, S, Arase, W C, Glasgow, A R, Brash, M, Anton, H, Kühn   +19 more
openaire   +2 more sources

Localization of arachidonate 12-lipoxygenase in canine brain tissues

Neuroscience Research Supplements, 1991
Abstract: The cytosol fraction from a thoroughly imgated canine cerebrum was subjected to immunoaffinity chromatography using a monoclonal antibody against porcine leukocyte 12‐lipoxygenase. Arachidonate 12‐lipoxygenase eluted from the column with some retardation. The enzyme, with a specific activity of 9 nmol/min/mg of protein, converted arachidonic
M, Nishiyama, H, Okamoto, T, Watanabe, T, Hori, T, Hada, N, Ueda, S, Yamamoto, H, Tsukamoto, K, Watanabe, T, Kirino   +9 more
openaire   +2 more sources

Molecular cloning and expression of human arachidonate 12-lipoxygenase

Biochemical and Biophysical Research Communications, 1990
The cDNA for a 12-lipoxygenase was isolated from cDNA library of human erythroleukemia cells. The cDNA had an open reading frame encoding 663 amino acids with a calculated molecular weight of 75,513. The deduced amino acid sequence of human 12-lipoxygenase exhibited 41.5%, 65.3% and 65.4% identity with human 5-lipoxygenase, human 15-lipoxygenase and ...
T, Yoshimoto, Y, Yamamoto, T, Arakawa, H, Suzuki, S, Yamamoto, C, Yokoyama, T, Tanabe, H, Toh   +7 more
openaire   +2 more sources

Platelet-Type Arachidonate 12-Lipoxygenase

1996
In human platelets arachidonic acid is released from membrane phospholipids by the catalysis of phosopholipase A2, and then oxygenated either by cyclooxygenase or by 12-lipoxygenase. It is well known that the cyclooxygenase pathway leads to the synthesis of pro-aggregatory and vasoconstrictive thromboxane A2.
M, Nakamura, N, Ueda, S, Yamamoto, K, Ishimura, K, Tomo, M, Okuma   +5 more
openaire   +2 more sources