Results 131 to 140 of about 17,329 (193)

Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta-cells

American Journal of Physiology-Endocrinology and Metabolism, 1992
The immunohistochemical distribution of arachidonate lipoxygenases in rat pancreas was characterized with specific polyclonal anti-5-lipoxygenase and anti-12-lipoxygenase antibodies. Immunohistochemical analysis of formaldehyde-fixed paraffin-embedded rat pancreas using anti-12-lipoxygenase antibody and biotin-avidin-peroxidase detection demonstrated ...
V R, Shannon, S, Ramanadham, J, Turk, M J, Holtzman   +3 more
openaire   +3 more sources

Arachidonate 12-lipoxygenases

Progress in Lipid Research, 1997
S, Yamamoto, H, Suzuki, N, Ueda
semanticscholar   +4 more sources

Analysis of non-heme iron in arachidonate 12-lipoxygenase of porcine leukocytes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
Arachidonate 12-lipoxygenase of porcine leukocytes, which was purified to homogeneity by immunoaffinity chromatography, was analyzed for iron content by atomic absorption spectrophotometry. The enzyme contained 0.70 +/- 0.09 g atom of iron per mol of enzyme (mean +/- S.D., n = 4).
S, Matsuda, H, Suzuki, T, Yoshimoto, S, Yamamoto, A, Miyatake   +4 more
openaire   +3 more sources

An overlapping lncRNA antisense to coding arachidonate 12‐lipoxygenase gene is ubiquitously expressed and exhibited cell‐type‐specific subcellular localization

The FASEB Journal, 2021
The arachidonate 12‐lipoxygenase (ALOX12) gene encodes an enzyme that acts on polyunsaturated fatty acid substrates and generates bioactive lipid mediators regulating a variety of biological processes associated with various disease pathologies.
M. Sabbir, Carla G. Taylor, P. Zahradka
semanticscholar   +1 more source

Arachidonate 12-lipoxygenases

Prostaglandins & Other Lipid Mediators, 2002
Arachidonate 12-lipoxygenase introduces a molecular oxygen at carbon 12 of arachidonic acid to generate a 12-hydroperoxy derivative. The enzymes generate 12-hydroperoxy derivatives with either S- or R-configurations. There are three isoforms of 12S-lipoxygenases named after the cells where they were first identified; platelet, leukocyte and epidermis ...
Tanihiro, Yoshimoto, Yoshitaka, Takahashi   +1 more
openaire   +2 more sources

Arachidonate 12-lipoxygenase (ALOX12) is differentially expressed in the tumors of breast cancer patients treated with trastuzumab.

, 2020
Trastuzumab (Herceptin) is a monoclonal antibody targeting the extracellular domain of the human epidermal growth factor receptor 2 (HER2) (1) utilized for the treatment of adjuvant and metastatic breast cancer (2) in the United States and worldwide.
Shahan Mamoor
semanticscholar   +1 more source

Mammalian Arachidonate 12-Lipoxygenases

1997
Since arachidonate 12-lipoxygenase was earlier found in platelets as the first mammalian lipoxygenase, the enzyme has been found in a variety of tissues of a number of animal species. On the basis of our studies in the last decade, we have demonstrated that there are two isoforms of 12-lipoxygenase (1).
S, Yamamoto, Y, Takahashi, T, Hada, H, Hagiya, H, Suzuki, G R, Reddy, N, Ueda, T, Arakawa, M, Nakamura, S, Matsuda, Y, Taketani, T, Yoshimoto, T, Azekawa, Y, Morita, K, Ishimura, S, Arase, W C, Glasgow, A R, Brash, M, Anton, H, Kühn   +19 more
openaire   +2 more sources

Platelet-Type Arachidonate 12-Lipoxygenase

1996
In human platelets arachidonic acid is released from membrane phospholipids by the catalysis of phosopholipase A2, and then oxygenated either by cyclooxygenase or by 12-lipoxygenase. It is well known that the cyclooxygenase pathway leads to the synthesis of pro-aggregatory and vasoconstrictive thromboxane A2.
M, Nakamura, N, Ueda, S, Yamamoto, K, Ishimura, K, Tomo, M, Okuma   +5 more
openaire   +2 more sources

Arachidonate 12-lipoxygenases with reference to their selective inhibitors

Biochemical and Biophysical Research Communications, 2005
Lipoxygenase is a dioxygenase recognizing a 1-cis,4-cis-pentadiene of polyunsaturated fatty acids. The enzyme oxygenates various carbon atoms of arachidonic acid as a substrate and produces 5-, 8-, 12- or 15-hydroperoxyeicosatetraenoic acid with a conjugated diene chromophore.
Shozo, Yamamoto, Michiko, Katsukawa, Ayumi, Nakano, Emi, Hiraki, Kohji, Nishimura, Mitsuo, Jisaka, Kazushige, Yokota, Natsuo, Ueda   +7 more
openaire   +2 more sources

Diurnal Change of Arachidonate 12-Lipoxygenase in Rat Pineal Gland

Biochemical and Biophysical Research Communications, 1997
Rat pineal gland contains a 12-lipoxygenase as demonstrated by the enzyme activity, RNA blot analysis and in situ hybridization. Using rats maintained with 12-h dark and light cycles, dynamic changes of the enzyme in pineal gland were examined. When the crude extract of pineal glands was incubated with arachidonic acid and the reaction products were ...
H, Kawajiri, N, Qiao, D M, Zhuang, T, Yoshimoto, H, Hagiya, S, Yamamoto, H, Sei, Y, Morita   +7 more
openaire   +2 more sources