Results 21 to 30 of about 10,969 (168)

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

Journal of Lipid Research, 2008
Many of the ichthyoses are associated with inherited disorders of lipid metabolism. These disorders have provided unique models to dissect physiologic processes in normal epidermis and the pathophysiology of more common scaling conditions.
Peter M. Elias, Mary L. Williams, Walter M. Holleran, Yan J. Jiang, Matthias Schmuth   +4 more
doaj   +1 more source

Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Fibrosis of the lungs is the final phase of many lung illnesses. Its characterized by excessive matrix production leading to the normal lung architecture destruction and eventually death.
Fatima Mohammad Saeed Mahdi , Mustafa Ghazi Alabbassi , Muthanna Ibrahim Al-Ezzi   +2 more
doaj   +1 more source

Immunohistochemical study of arachidonate 12-lipoxygenase in porcine tissues. [PDF]

Journal of Histochemistry & Cytochemistry, 1989
12-Lipoxygenase oxygenates the 12 position of arachidonic acid and produces its 12-hydroperoxy derivative. The enzyme is found in greatest amounts in porcine leukocytes and is distributed widely in various other tissues. An anti-12-lipoxygenase antibody was raised in rabbits with the immunoaffinity-purified enzyme as an antigen and was used in ...
T, Maruyama, N, Ueda, T, Yoshimoto, S, Yamamoto, N, Komatsu, K, Watanabe   +5 more
openaire   +2 more sources

Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Leukocyte‐directed biosynthesis of specialized proresolving mediators (SPMs) orchestrates physiological inflammation after myocardial infarction.
Amanda B. Pullen, Vasundhara Kain, Charles N. Serhan, Ganesh V. Halade   +3 more
doaj   +1 more source

Platelets Proteomic Profiles of Acute Ischemic Stroke Patients. [PDF]

PLoS ONE, 2016
Platelets play a crucial role in the pathogenesis of stroke and antiplatelet agents exist for its treatment and prevention. Through the use of LC-MS based protein expression profiling, platelets from stroke patients were analyzed and then correlated with
Ozge Cevik, Ahmet Tarik Baykal, Azize Sener   +2 more
doaj   +1 more source

Genome-wide comparative analyses for selection signatures indicate candidate genes for between-breed variability in copper accretion in sheep

Animal
The problem of copper (Cu) intoxication and deficiency continues to impact economic gains and animal welfare in sheep husbandry. This study investigated the ovine genome for regions and potential genes under selection for Cu accretion between sheep ...
O.O. Adeniyi, J.A. Lenstra, S. Mastrangelo, G. Lühken   +3 more
doaj   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation.

PLoS ONE, 2015
IntroductionThere is a high degree of inter-individual variability among people in response to intervention with omega-3 fatty acids (FA), which may partly explain conflicting results on the effectiveness of omega-3 FA for the treatment and prevention of
Claire C Berthelot, Shizuo George Kamita, Romina Sacchi, Jun Yang, Malin L Nording, Katrin Georgi, Christine Hegedus Karbowski, J Bruce German, Robert H Weiss, Ronald J Hogg, Bruce D Hammock, Angela M Zivkovic   +11 more
doaj   +1 more source