Results 21 to 30 of about 17,329 (193)

ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens, with data on DNA, on the protein encoded, and where the gene is implicated.
A Erdog, S Banerjee
openaire   +1 more source

Albumin redirects platelet eicosanoid metabolism toward 12(S)-hydroxyeicosatetraenoic acid.

Journal of Lipid Research, 1989
Albumin is a major determinant of eicosanoid formation, affecting autacoids important in cell-cell interactions. We delineated three mechanisms by which albumin controlled platelet eicosanoid formation: 1) Albumin diverted free arachidonate toward 12 ...
M J Broekman, A M Eiroa, A J Marcus
doaj   +1 more source

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

Journal of Lipid Research, 1994
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15 ...
H Kühn, J Belkner, H Suzuki, S Yamamoto
doaj   +1 more source

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Metabolites, 2023
Psoriasis is immune-mediated skin disorder affecting thousands of people. Sphingolipids (SLs) are bioactive molecules present in the epidermis, involved in the following cellular processes: proliferation, differentiation, and apoptosis of keratinocytes ...
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues   +3 more
doaj   +1 more source

Evidence for cytokine regulation of cholesterol metabolism in herpesvirus-infected arterial cells by the lipoxygenase pathway.

Journal of Lipid Research, 1990
Cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1), and gamma-interferon (IF) are produced by activated hematopoietic cells. They possess antiviral activity and have other biological activities such as induction of cell proliferation and
OR Etingin, DP Hajjar
doaj   +1 more source

RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model

BMC Genomics, 2021
Background Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome effects of Traumeel (Tr14), a multicomponent natural product, and diclofenac, a non ...
Georges St. Laurent, Ian Toma, Bernd Seilheimer, Konstantin Cesnulevicius, Myron Schultz, Michael Tackett, Jianhua Zhou, Maxim Ri, Dmitry Shtokalo, Denis Antonets, Tisha Jepson, Timothy A. McCaffrey   +11 more
doaj   +1 more source

Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury

Antioxidants, 2021
This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-induced acute liver injury and the underlying molecular mechanisms.
Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov, Jianzhong Shen   +5 more
doaj   +1 more source

Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles.

Biological and Pharmaceutical Bulletin, 2017
The human hair shaft is covered with multiple scale-like cuticular layers. During the terminal differentiation stage of immature cuticular cells within the hair follicle, cysteine-rich calcium binding S100A3 protein is predominantly translated, and its ...
K. Kizawa, Takeshi Fujimori, T. Kawai
semanticscholar   +1 more source

Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway

JCI Insight, 2022
In this investigation, a potentially novel signaling pathway in gentamicin-induced acute kidney injury—worsened by overexpression of proximal tubular enzyme, myo-inositol oxygenase (MIOX)—was elucidated.
Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S. Kanwar   +3 more
doaj   +1 more source

Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis

Frontiers in Immunology, 2020
Alcoholism is one of the leading and increasingly prevalent reasons of liver associated morbidity and mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options.
Alexander Queck, Annika F. Fink, Evelyn Sirait-Fischer, Sabrina Rüschenbaum, Dominique Thomas, Ryan G. Snodgrass, Gerd Geisslinger, Gerd Geisslinger, Hideo A. Baba, Jonel Trebicka, Jonel Trebicka, Jonel Trebicka, Jonel Trebicka, Stefan Zeuzem, Andreas Weigert, Christian M. Lange, Bernhard Brüne, Bernhard Brüne   +17 more
doaj   +1 more source