Results 31 to 40 of about 10,969 (168)

Interactions between the Parasite Philasterides dicentrarchi and the Immune System of the Turbot Scophthalmus maximus. A Transcriptomic Analysis

Biology, 2020
The present study analyses the interactions between Philasterides dicentrarchi (a ciliate parasite that causes high mortalities in cultured flatfish) and the peritoneal cells of the turbot Scophthalmus maximus during an experimental infection.
Alejandra Valle, José Manuel Leiro, Patricia Pereiro, Antonio Figueras, Beatriz Novoa, Ron P. H. Dirks, Jesús Lamas   +6 more
doaj   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population

Clinical and Experimental Hypertension, 2018
Background: Coronary artery disease (CAD) is major cause of death and morbidity worldwide. Arachidonate 12/15-lipoxygenase (ALOX) is a member of the lipid peroxidizing enzyme family and implicated in the pathogenesis of atherosclerosis, but with ...
Naindeep Kaur, Jagtar Singh, Sreenivas Reddy   +2 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Nature Communications
Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with
Jiayan Jin, Zeyu Zheng, Jiaxuan Gu, Qibin Zhang, Zhikun Xu, Zhenhua Feng, Siyue Tao, Shumin He, Jiao Cheng, Jian Wang, Hou-Feng Zheng, Shishi Li, Fengdong Zhao, Jian Chen   +13 more
doaj   +1 more source

Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells

Journal of Biological Chemistry, 1993
A homogenate of epidermal cells isolated from human skin converted arachidonic acid to 12S-hydroxy-5, 8,10,14-eicosatetraenoic acid and 15-hydroxy-5, 8,11,13-eicosatetraenoic acid as the main lipoxygenase products. The production of these hydroxy acids was not stimulated by the addition of 1 mM NADPH required for cytochrome P-450 reaction, but ...
Y, Takahashi, G R, Reddy, N, Ueda, S, Yamamoto, S, Arase   +4 more
openaire   +2 more sources

Distinct Interferon and Intracellular Signaling Signatures in Systemic Lupus Erythematosus and Dermatomyositis by Integrative Transcriptomic and Proteomic Analysis

ACR Open Rheumatology, Volume 8, Issue 2, February 2026.
Objective Transcript and protein abundance data were measured to compare biologic pathway effects in the peripheral blood of patients diagnosed with systemic lupus erythematosus (SLE) and dermatomyositis (DM) who receive immunosuppressive therapies. Methods Expression data from the peripheral blood of patients with SLE (n = 41) and DM (n = 14) were ...
James M. Ward, Mythri Ambatipudi, Zerai Manna, Adam Schiffenbauer, Michael A. Smith, Saifur Rahman, Frederick W. Miller, Mariana J. Kaplan, Jian‐Liang Li, Kerry A. Casey, Sarfaraz Hasni, Lisa G. Rider   +11 more
wiley   +1 more source

Platelet-type Arachidonate 12-Lipoxygenase in Mouse Gastrointestinal Tract.

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1998
12-Lipoxygenase enzyme oxygenates the position 12 of arachidonic acid, and produces 12S-hydroperoxy-arachidonic acid. When mouse gastrointestinal tract was immunostained with an antiserum against human platelet 12-lipoxygenase and examined by light microscopy, positively-stained cells were found in the epithelium of stomach and small and large ...
Michihiro Nakamura, Shozo Yamamoto, Kazunori Ishimura   +2 more
openaire   +2 more sources

The transcriptional regulation of human arachidonate 12‐lipoxygenase gene by NFκB/Rel [PDF]

FEBS Letters, 1995
As examined by the luciferase assay, a negative regulatory region including the NFκB motif was found in the 5′‐flanking region of the 12‐lipoxygenase gene in human erythroleukemia cells. The negative control was abolished by a site‐specific mutation of the NFκB motif. Probes including the NFκB region gave positive bands upon a gel‐shift assay.
Arakawa, Toshiya, Nakamura, Michihiro, Yoshimoto, Tanihiro, Yamamoto, Shozo   +3 more
openaire   +2 more sources

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source