Results 61 to 70 of about 17,329 (193)

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis

Hereditas
Background Gastric cancer (GC) remains a significant global health challenge due to its high mortality and frequent resistance to chemotherapy drugs like cisplatin (DDP). Carnosic acid (CA), a phenolic diterpene, exhibits potential anti-cancer properties.
Li Zhou, Bin Xu, Baojian Li
doaj   +1 more source

Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

Efficacy and Mechanism Evaluation, 2015
Background: The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear. Previous work has been equivocal. Variation in copy numbers of the specificity protein 1-binding motif in the arachidonate 5-lipoxygenase (ALOX5 ...
Chinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, Jonathan Grigg   +13 more
doaj   +1 more source

Targeting of the Alox12-12-HETE in Blast Crisis Chronic Myeloid Leukemia Inhibits Leukemia Stem/Progenitor Cell Function

Cancer Management and Research, 2020
Si Gao,1,2,* Jialin Hu,3,* Yong Li4 1Department of Haematology and Rheumatology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2The Central ...
Gao S, Hu J, Li Y
doaj  

Effect of pulsed electromagnetic field treatment on programmed resolution of inflammation pathway markers in human cells in culture

Journal of Inflammation Research, 2015
Nicole J Kubat,1 John Moffett,2 Linley M Fray2 1Nicole Kubat Consulting, Pasadena, CA, USA; 2Life Science Department, Regenesis Biomedical, Inc., Scottsdale, AZ, USA Abstract: Inflammation is a complex process involving distinct but overlapping ...
Kubat NJ, Moffett J, Fray LM
doaj  

Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis

Frontiers in Immunology
Visceral leishmaniasis (VL), the most severe form of leishmaniasis, remains a significant public health concern that cannot be overlooked in underdeveloped regions.
Dongmei Yuan, Hanxiao Qin, Zeying Yu
doaj   +1 more source

Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11

BMC Complementary Medicine and Therapies
Background Luteolin (3,4,5,7-tetrahydroxy flavone) is reported to strongly protect from acute carbon tetrachloride (CCl4) -induced liver injury or fibrosis. Ferroptosis can be induced by hepatic injury, and contributes to liver fibrosis development.
Zhiqiang Han, Batudeligen, Hongmei Chen, Narisu, Anda, Yanhua Xu, Lan Xue   +6 more
doaj   +1 more source

DNA methylation and stroke prognosis: an epigenome-wide association study

Clinical Epigenetics
Background and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetics, including DNA ...
Joan Jiménez-Balado, Isabel Fernández-Pérez, Cristina Gallego-Fábrega, Uxue Lazcano, Carolina Soriano-Tárraga, Marta Vallverdú-Prats, Marina Mola-Caminal, Lucía Rey-Álvarez, Adrià Macias-Gómez, Antoni Suárez-Pérez, Eva Giralt-Steinhauer, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Ángel Ois, Manel Esteller, Jaume Roquer, Israel Fernández-Cadenas, Jordi Jiménez-Conde   +17 more
doaj   +1 more source

Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via Nrf2/GPX4 signaling

BMC Gastroenterology
Background Irisin, a recently identified protein that is released during exercise and promotes the transformation of white adipocytes into brown adipocytes.
Zhenyu Li, Beile Wang, Xinyu Li
doaj   +1 more source

ISEV2025 Abstract Book

Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source