Results 101 to 110 of about 16,216 (223)
PLOS ONE, 2020 AbstractAmong the first steps in inflammation is the conversion of arachidonic acid (AA) stored in the cell membranes into leukotrienes. This occurs mainly in leukocytes and depends on the interaction of two proteins: 5-lipoxygenase (5LO), stored away from the nuclear membranes until use and 5-lipoxygenase activating protein (FLAP), a transmembrane ...
Ramakrishnan B. Kumar +3 more
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Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.Phytochemicals derived from medicinal plants represent a rich and largely underexploited source of anti‐inflammatory and immunomodulatory agents. Chronic inflammation and dysregulated immune responses underpin many tropical and global diseases, including infectious, autoimmune, and metabolic disorders. This review examines the spectrum of plant‐derived
Md Asaduzzaman +4 more
wiley +1 more source
Arachidonate 5-Lipoxygenase Variants in Atherosclerosis, Obesity, and Bone Traits [PDF]
Circulation Research, 2006 To the Editor: I write regarding publications by Mehrabian et al1,2 appearing in Circulation Research and a subsequent publication by Kuhn et al3 appearing in Arteriosclerosis, Thrombosis, and Vascular Biology . The key implication from the combination of these reports was that amino acid substitutions in arachidonate 5-lipoxygenase (ALOX5) could ...
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Japanese Journal of Pharmacology, 2000 To investigate the cellular sources of arachidonate metabolites during asthma, in vitro productions of thromboxane (TX) B2, prostaglandin (PG) D2, leukotriene (LT) B4 and cysteinyl (Cys) LTs from guinea pig eosinophils and macrophages simultaneously stimulated with the Ca ionophore A23187 were investigated.
T, Nabe, M, Miura, T, Kamiki, S, Kohno
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Bone ResearchNociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear.
Xuanyu Qi +7 more
doaj +1 more source
Preliminary assessment of differential expression of candidate genes associated with atherosclerosis [PDF]
, 2013 Identifying susceptible genes associated with the pathogenesis of atherosclerosis (ATH) may contribute toward better management of this condition. This preliminary study was aimed at assessing the expression levels of 11 candidate genes, namely tumor ...
Ahmad, Zalinah +5 more
core +1 more source
Multi-walled carbon nanotubes induce arachidonate 5-lipoxygenase expression and enhance the polarization and function of M1 macrophages <i>in vitro</i>. [PDF]
Nanotoxicology, 2023 Lim CS +4 more
europepmc +1 more source
Fatty acids in veterinary medicine and research [PDF]
, 2017 Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the body ...
Mostyn, Alison +2 more
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Dual role of the p38 \(MAPK/cPLA_2\) pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists [PDF]
, 2013 p38 Mitogen-activated protein (MAP) kinase is involved in the apoptosis of nucleated cells. Although platelets are anucleated cells, apoptotic proteins have been shown to regulate platelet lifespan.
Gambaryan, S. +3 more
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Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis [PDF]
, 2014 BACKGROUND & AIMS: A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
Bell, Lauren N. +4 more
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