Results 111 to 120 of about 16,216 (223)

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Journal of Biological Chemistry, 1993
Bone resorption requires cooperation between osteoclasts and mononuclear accessory cells by mechanisms which have not been elucidated. Since multinucleated cells in giant cell tumors of bone have many phenotypic and functional characteristics of normal osteoclasts, we have examined the interaction between the bone-resorbing multinucleated cells and the
W E, Gallwitz, G R, Mundy, C H, Lee, M, Qiao, G D, Roodman, M, Raftery, S J, Gaskell, L F, Bonewald   +7 more
openaire   +2 more sources

Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study. [PDF]

Int J Environ Res Public Health, 2023
Jin S, Choi EJ, Choi YJ, Min WK, Park JY, Yoon SZ.   +5 more
europepmc   +1 more source

Expresión diferencial de genes en Pyropia columbina (Bangiales, Rhodophyta) bajo hidratación y desecación natural [PDF]

, 2013
Indexación: Web of Science; Scielo.RESUMEN. En Zonas Costeras rocosas, la desecación es gatillada porción Cambios Diarios en los Niveles de marea, y la Evidencia indica experimental de Me Distribución de las algas en la zona intermareal no está ...
Contreras-Porcia, Loretto, Correa, Juan A., Fierro, Camila, Flores-Molina, María Rosa, Guajardo, Eduardo, Kube, Michael, Lovazzano, Carlos, López-Cristoffanini, Camilo, Núñez, Alejandra, Reinhardt, Richard, Thomas, Daniela   +10 more
core  

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]

, 2019
BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A, Coelho, N, Correia, MJ, Gonçalves-Dias, C, Macedo, MP, Monteiro, E, Morello, J, Soto, K, et al.   +7 more
core   +1 more source

Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase [PDF]

, 2017
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population.
Anderson, Ryan M., Chalasani, Naga, Mirmira, Raghavendra G., Samala, Niharika, Tersey, Sarah A.   +4 more
core   +1 more source

Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis [PDF]

, 2017
An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process.
Bray, Michael A., Hengstler, Bruno, Rich, Roland, Tomasz, Alexander, Tuomanen, Elaine, Zak, Oto   +5 more
core  

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]

, 2016
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana, Gibson Dilthey, Beverly, Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Kovacs, Attila, Liu, Xinping, Mancuso, David J, Moon, Sung Ho, Nguyen, Annie L, Sims, Harold F, Weinheimer, Carla J, Yang, Kui   +12 more
core   +2 more sources

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

Mediators of Inflammation, 2016
Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators.
Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur   +4 more
doaj   +1 more source

Dimerization of human 5-lipoxygenase [PDF]

, 2017
Human 5-lipoxygenase (5-LO) can form dimers as shown here via native gel electrophoresis, gel filtration chromatography and LILBID (laser induced liquid bead ion desorption) mass spectrometry.
Brutschy, Bernhard, Cernescu, Mihaela, Ermisch, Michael, Hofmann, Bettina, Häfner, Ann-Kathrin, Hörnig, Michael, Metzner, Julia, Schneider, Gisbert, Steinhilber, Dieter   +8 more
core  

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Beaven, Michael A., Gilfillan, Alasdair M., Kim, Mi-Sun, Kuehn, Hye Sun, Metcalfe, Dean D., Swindle, Emily J.   +5 more
core   +1 more source