Results 41 to 50 of about 3,171 (185)

Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
This Mendelian randomization analysis elucidates causal pathways linking gut microbiota and serum metabolites to meningioma. We identified specific risk factors and found that arachidonic acid potentially mediates the effect of CAG−873 sp001701165 on meningioma risk.
Xuanli Gong, Jinxiang Zhang, Mengjiao He, Xiaochen Zhang, Kelan Wang, Yulu Yang, Qingyun Zhao, Xin Zhao, Wei Zou   +8 more
wiley   +1 more source

Eicosanoid control over antigen presenting cells in asthma [PDF]

, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth, Aliberti, Angeli, Baratelli, Barnes, Barnig, Barrett, Barrett, Betz, Bhattacharya, Blaho, Boniface, Bourdonnay, Brash, Cai, Chang, Chen, Clarke, de, de, Doherty, Draijer, Dullaers, Dwyer, Everts, Fajt, Fedyk, Funk, Gao, Gao, Gauvreau, George, Giannattasio, Goodarzi, Guilliams, Guilliams, Hajek, Hallstrand, Hallstrand, Hamilton, Hammad, Hammad, Hammad, Hammad, Hammad, Hardy, Harizi, Harizi, Harizi, Hattori, Haworth, Hedi, Henderson, Herrerias, Hilkens, Hirai, Huang, Hunter, Idzko, Jaffar, Jaffar, Jandl, Johnston, Kalinski, Kalinski, Kalinski, Kanaoka, Kay, Khare, Khayrullina, Kolodsick, Kool, Kühn, Lambrecht, Lambrecht, Lambrecht, Lamoureux, Lauzon-Joset, Lee, Legler, Leigh, Levy, Levy, Levy, Levy, Levy, Linton, Liu, Lombardi, Lukic, Lundequist, Lynch, Machida, Maher, Manning, Maric, Medoff, Mirchandani, Miyahara, Mori, Murn, Muñoz, Nagao, Nagata, Nakano, Nataraj, Norimoto, Nothacker, Ohta, Okunishi, Oliphant, Oriss, Parameswaran, Pavord, Peters-Golden, Pettipher, Phythian-Adams, Planagumà, Plantinga, Prinz, Raymond, Rieser, Rieser, Robbiani, Rodríguez-Pinto, Rogerio, Roper, Roper, Roper, Rubio, Salimi, Samuchiwal, Samuchiwal, Scandella, Schlitzer, Schuijs, Semmrich, Serhan, Sestini, Sheibanie, Shiraishi, Shirey, Shirey, Snijdewint, Speth, Steinbrink, Sturm, Szczeklik, Tager, Tanaka, Tang, Tang, Tang, Terawaki, Thornton, Tilley, Torres, Torres, Upham, van, van, van, van, van, Vassiliou, Vieira, Walker, Wenzel, Westphalen, Willart, Williams, Xue, Yamabayashi, Yamaguchi, Yamaoka, Yang, Zasłona, Zasłona, Zhou, Zhou, Çelik   +180 more
core   +2 more sources

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen [PDF]

, 2011
Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical ...
B. Baragatti, F. Coceani
core   +1 more source

Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current [PDF]

, 2004
Pyramidal neurons in the lateral amygdala discharge trains of action potentials that show marked spike frequency adaptation, which is primarily mediated by activation of a slow calcium-activated potassium current.
Faber, E. S. L., Sah, P.
core   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source