Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi +8 more
wiley +1 more source
Interactions between prostaglandins, leukotrienes and HIV-1: Possible implications for the central nervous system [PDF]
, 2012 In HIV-1-infected individuals, there is often discordance between viremia in peripheral blood and viral load found in the central nervous system (CNS). Although the viral burden is often lower in the CNS compartment than in the plasma, neuroinflammation ...
Jonathan Bertin +3 more
core +2 more sources
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]
, 2018 Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus +2 more
core +2 more sources
Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target
Allergy, EarlyView.
A. Weingaertner, T. Eiwegger
wiley +1 more source
Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current [PDF]
, 2004 Pyramidal neurons in the lateral amygdala discharge trains of action potentials that show marked spike frequency adaptation, which is primarily mediated by activation of a slow calcium-activated potassium current.
Faber, E. S. L., Sah, P.
core +1 more source
Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5
British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino +7 more
wiley +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, Volume 2, Issue 1, Page 106-129, March 2026.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways [PDF]
, 2009 Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of ...
Cavaleiro, José +6 more
core +2 more sources
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Human bronchial fibroblasts express the 5-lipoxygenase pathway [PDF]
, 2006 Background Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators.
Anna J James +4 more
core +2 more sources