Results 41 to 50 of about 3,184 (177)

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets [PDF]

, 2014
High-fat diets lead to obesity, inflammation, and dysglycemia. 12-Lipoxygenase (12-LO) is activated by high-fat diets and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates.
Maganti, Aarthi V., Maier, Bernhard, Mirmira, Raghavendra G., Nadler, Jerry L., Nishiki, Yurika, Tersey, Sarah A.   +5 more
core   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Eicosanoid control over antigen presenting cells in asthma [PDF]

, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth, Aliberti, Angeli, Baratelli, Barnes, Barnig, Barrett, Barrett, Betz, Bhattacharya, Blaho, Boniface, Bourdonnay, Brash, Cai, Chang, Chen, Clarke, de, de, Doherty, Draijer, Dullaers, Dwyer, Everts, Fajt, Fedyk, Funk, Gao, Gao, Gauvreau, George, Giannattasio, Goodarzi, Guilliams, Guilliams, Hajek, Hallstrand, Hallstrand, Hamilton, Hammad, Hammad, Hammad, Hammad, Hammad, Hardy, Harizi, Harizi, Harizi, Hattori, Haworth, Hedi, Henderson, Herrerias, Hilkens, Hirai, Huang, Hunter, Idzko, Jaffar, Jaffar, Jandl, Johnston, Kalinski, Kalinski, Kalinski, Kanaoka, Kay, Khare, Khayrullina, Kolodsick, Kool, Kühn, Lambrecht, Lambrecht, Lambrecht, Lamoureux, Lauzon-Joset, Lee, Legler, Leigh, Levy, Levy, Levy, Levy, Levy, Linton, Liu, Lombardi, Lukic, Lundequist, Lynch, Machida, Maher, Manning, Maric, Medoff, Mirchandani, Miyahara, Mori, Murn, Muñoz, Nagao, Nagata, Nakano, Nataraj, Norimoto, Nothacker, Ohta, Okunishi, Oliphant, Oriss, Parameswaran, Pavord, Peters-Golden, Pettipher, Phythian-Adams, Planagumà, Plantinga, Prinz, Raymond, Rieser, Rieser, Robbiani, Rodríguez-Pinto, Rogerio, Roper, Roper, Roper, Rubio, Salimi, Samuchiwal, Samuchiwal, Scandella, Schlitzer, Schuijs, Semmrich, Serhan, Sestini, Sheibanie, Shiraishi, Shirey, Shirey, Snijdewint, Speth, Steinbrink, Sturm, Szczeklik, Tager, Tanaka, Tang, Tang, Tang, Terawaki, Thornton, Tilley, Torres, Torres, Upham, van, van, van, van, van, Vassiliou, Vieira, Walker, Wenzel, Westphalen, Willart, Williams, Xue, Yamabayashi, Yamaguchi, Yamaoka, Yang, Zasłona, Zasłona, Zhou, Zhou, Çelik   +180 more
core   +2 more sources

Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair. [PDF]

, 2017
The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFA) of the n-6 and n-3 series, respectively. Both are essential for optimal brain development and function.
A Artmann, A Berger, A Bilkei-Gorzo, A Chicca, A Nadjar, A Petroni, A Piyanova, A Tanimura, A Thomazeau, A Thomazeau, A Viader, AA Farooqui, AE Bonnet, AF Domenichiello, AJ Vecchio, AL Groeger, AM Fjell, AP Simopoulos, B Batetta, B Lands, B Lu, BM Fonseca, BN Ames, C Arnold, C Canugovi, C Cipollina, CD Breder, CD Buckley, CE Ramsden, CN Serhan, CN Serhan, CN Serhan, CN Serhan, CT Chen, D Bagga, D Ehninger, D Kempuraj, D Leung, D Piomelli, D Rueda, DK Nomura, E Lien, E Mantzioris, E Molina-Holgado, E Ryberg, EA Placzek, EM Novak, ES Onaivi, G Kaur, GA Garden, GF Grabner, H Sprecher, H Yang, H Yang, HG Kuhn, I Galve-Roperh, I Katona, I Matias, J Liu, JC DeMar Jr, JC Demar Jr, JE Tungen, JF Quinn, JL Harrison, JM Parent, JP Pan, JR Savinainen, JT Wood, JW Phillis, JY Xu, K Jin, K Tsuboi, K Yamagata, K Yurko-Mauro, KD Patel, KD Stark, KE Hopperton, KS Broughton, L Belayev, L Petrocellis De, M Alhouayek, M Aursnes, M Gabbs, M Gabrielli, M Kano, M Lafourcade, M Mecha, M Ouellet, M Perluigi, M Zhu, MA Rashid, MB Goncalves, ME Tremblay, MG Cascio, MK Gregory, MR Flock, MV Sofroniew, MV Sofroniew, N Murataeva, N Murataeva, N Stella, NG Bazan, NG Bazan, NG Bazan, NG Bazan, NR Yerram, P Urquhart, PE Castillo, PJ Jones, PK Yip, R Luostarinen, R Micha, R Yang, RJ Kulmacz, S Forsyth, S Watanabe, S Zelasko, SA Moore, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Strike, SE O’Sullivan, Simon C. Dyall, SN Lim, SU Kim, T Aguado, T Bartsch, T Cassano, T Cederholm, T Larrieu, T Takizawa, TVP Bliss, V Chhor, V Darsalia, V Marzo Di, V Marzo Di, V Smedt-Peyrusse De, W Jiang, WL Huang, X Chen, Y Marchalant, Y Takagi, Y Tian, YC Yung, ZZ Xu   +147 more
core   +1 more source

Targeting Ferroptosis Pathways for Synaptic Protection in Sevoflurane‐Induced Cognitive Impairment: A Nanomedicine Approach

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sevoflurane exposure triggers iron‐dependent lipid peroxidation and ferroptosis, leading to synaptic damage and cognitive dysfunction. Targeted nanodelivery systems that cross the blood–brain barrier can precisely modulate ferroptotic pathways, reduce oxidative injury, and rescue synaptic integrity, offering a promising strategy for preventing ...
Bin Zhao, Changming Wang, Mingming Zhang
wiley   +1 more source

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm, Volume 7, Issue 4, April 2026.
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
wiley   +1 more source

The emerging role of oxylipins in thrombosis and diabetes. [PDF]

, 2014
The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes.
Ahmed, Intekhab, Holinstat, Michael, Tourdot, Benjamin E   +2 more
core   +3 more sources

In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre‐Clinical Rodent Model

Prenatal Diagnosis, Volume 46, Issue 4, Page 546-555, April 2026.
ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde, Stephanie Finoti, Marc Oria, Jose L. Peiro   +3 more
wiley   +1 more source