Results 51 to 60 of about 3,155 (186)

ALOX15 (arachidonate 15-lipoxygenase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX15 (arachidonate 15-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. [PDF]

, 1979
Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11 ...
Goetzl, EJ, Sun, FF
core  

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX12 (arachidonate 12-lipoxygenase) Homo sapiens, with data on DNA, on the protein encoded, and where the gene is implicated.
A Erdog, S Banerjee
openaire   +1 more source

Trained Immunity and Cardiovascular Risk: An Immunological Perspective

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Systemic inflammation is a key driver of atherogenesis and its complications. While anti‐inflammatory therapies targeting pathways such as IL‐1β and IL‐6 have shown promise in established atherosclerotic cardiovascular disease (ASCVD), potential systemic effects raise concerns about immune suppression and infection, underscoring the need for ...
Katherine A. Boden, Jason Chai, Tafadzwa T. J. Kufazvinei, Robin P. Choudhury   +3 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Network Pharmacology Combined With Gut Microbiome and Serum Metabolomics Reveals the Therapeutic Mechanisms of Hydroxysafflor Yellow A in Diabetic Kidney Disease

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic kidney disease (DKD) is a severe complication of diabetes, primarily driven by chronic inflammation, oxidative stress, and gut microbiota dysbiosis. Hydroxysafflor yellow A (HSY), a bioactive compound derived from Carthamus tinctorius L., demonstrates promising renoprotective effects.
Pingping Wang, Xinyu Liu, Wen Sun, Xueyun Dong, Jiajun Tan, Min Chen, Jiayuan He, Asmaa Ali, Liang Wu, Keke Shao, Huantian Cui   +10 more
wiley   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]

, 2016
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana, Gibson Dilthey, Beverly, Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Kovacs, Attila, Liu, Xinping, Mancuso, David J, Moon, Sung Ho, Nguyen, Annie L, Sims, Harold F, Weinheimer, Carla J, Yang, Kui   +12 more
core   +2 more sources

Molecular Mechanisms of Anti‐Inflammatory and Immunomodulatory Activities of Key Phytochemicals: A Comprehensive Review

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Phytochemicals derived from medicinal plants represent a rich and largely underexploited source of anti‐inflammatory and immunomodulatory agents. Chronic inflammation and dysregulated immune responses underpin many tropical and global diseases, including infectious, autoimmune, and metabolic disorders. This review examines the spectrum of plant‐derived
Md Asaduzzaman, Lutfun Nahar, Mohammad Shahangir Biswas, Md. Matiar Rahman, Zhengwei Huang   +4 more
wiley   +1 more source