Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca\u3csup\u3e2+\u3c/sup\u3e regulation [PDF]
, 2012 Lipoxygenases (LOXs) are a key part of several signaling pathways that lead to inflammation and cancer. Yet, the mechanisms of substrate binding and allosteric regulation by the various LOX isoforms remain speculative.
Eek, Priit +5 more
core +2 more sources
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer [PDF]
, 2003 The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases.
Adrian, Thomas E +2 more
core +3 more sources
Hypoxia and lipid signaling [PDF]
, 2017 Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and ...
Huwiler, Andrea, Pfeilschifter, Josef
core
UEG Week 2025 Poster Presentations
United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley +1 more source
Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore [PDF]
, 2018 Cedars, Ari M. +8 more
core +2 more sources
MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E2. [PDF]
Stem Cell Res TherBermejo-Álvarez I +6 more
europepmc +1 more source
Altering 15-Lipoxygenases to 18-Lipoxygenases and Their Application to the Production of 5,18-Dihydroxyeicosapentaenoic Acids. [PDF]
Biotechnol BioengLee J, Kang SH, Lee TE, Oh DK.
europepmc +1 more source