Results 191 to 200 of about 127,455 (327)

No Effect of Low‐Dose Aspirin Versus Placebo as Add‐On Treatment in Bipolar Disorder—Results From a Randomised Controlled Trial (the A‐Bipolar RCT)

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Robust evidence associates immunoinflammatory dysfunction and bipolar disorder (BD), with immune dysregulation present in patients newly diagnosed with BD. This suggests that anti‐inflammatory agents, like low‐dose aspirin (LDA), might be repurposed in the treatment of early‐stage BD.
Caroline Fussing Bruun, Helle B. Krogh, Jeff Zarp, Julie Ravneberg Stokholm, Julie Lyng Forman, Kamilla Woznica Miskowiak, Annamaria Giraldi, Maj Vinberg, Maria Faurholt‐Jepsen, Lars Vedel Kessing   +9 more
wiley   +1 more source

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling [PDF]

, 2017
Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Li, Maoyin, Liu, Gao-Yuan, Moon, Sung Ho, Sims, Harold F   +6 more
core   +2 more sources

Stimulus-specific induction of phospholipid and arachidonic acid metabolism in human neutrophils [PDF]

, 1987
RW Godfrey, R. M. Manzi, M.C. Clark, S.T. Hoffstein   +3 more
openalex   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Involvement of Group VI Ca2+-independent Phospholipase A2 in Protein Kinase C-dependent Arachidonic Acid Liberation in Zymosan-stimulated Macrophage-like P388D1 Cells [PDF]

, 1999
Satoshi Akiba, Shingo Mizunaga, Keisuke Kume, Misako Hayama, Takashi Sato   +4 more
openalex   +1 more source

An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys

, 1981
Roy Patterson, Jacob J. Pruzansky, Kathleen E. Harris   +2 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Fatty Acids Dysregulation Correlates with Lung Function in Idiopathic Pulmonary Fibrosis. [PDF]

Lung
Scialò F, Pagliaro R, Gelzo M, Matera MG, D'Agnano V, Zamparelli SS, Castaldo G, Cazzola M, Bianco A, Perrotta F.   +9 more
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source