Results 221 to 230 of about 5,117,744 (378)

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

open access: yesSmall Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz   +5 more
wiley   +1 more source

Inhibition of cytotoxic T lymphocyte-mediated lysis by ETYA: effect independent of arachidonic acid metabolism. [PDF]

open access: bronze, 1985
Alan S. Taylor   +4 more
openalex   +1 more source

Bisphenol A Induces Neuronal Apoptosis and Oxidative Stress Through TRPV4 Channel Signaling Pathways: Protective Role of Alpha‐Lipoic Acid

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), an environmental toxin, exerts adverse effects by increasing mitochondrial (mROS) and intracellular (iROS) reactive oxygen species, apoptosis, and Ca2+ influx in neurological diseases. However, antioxidants can mitigate these detrimental effects. This study aimed to investigate the protective role of antioxidant alpha‐lipoic
Ramazan Çinar, Mustafa Nazıroğlu
wiley   +1 more source

The role of the host—Neutrophil biology

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple   +4 more
wiley   +1 more source

Multi‐Omics Analysis of Ileal Mucosa and Mesentery Before and After Ileocecal Resection in Crohn's Disease

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic disorder involving any part of the gastrointestinal tract. Ileocecal resection may serve as a more effective treatment option for early CD. However, the potential relationship and mechanisms between the ileocecum and remission induction of CD are still elusive.
Kai Xia   +15 more
wiley   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

open access: yesUroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang   +3 more
wiley   +1 more source

Peroxidation of arachidonic acid by human platelets

open access: bronze, 1977
Minoru Okuma   +2 more
openalex   +2 more sources

Deciphering the panvascular immune landscape of atherosclerosis

open access: yesVIEW, EarlyView.
Atherosclerosis (AS) involves inflammation in major arteries and can cause severe cardiovascular events like heart attacks and strokes, yet disease patterns vary significantly between arteries, complicating diagnosis and treatment. In this study, we integrated transcriptomic and single‐cell RNA sequencing data from AS plaques across five key arterial ...
Yiming Zhong   +12 more
wiley   +1 more source

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