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Annual Review of Biochemistry, 1986
C YC LOO XYGENASE PRODUC TS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 70 Prostaglandin Endoperoxide Synthase 70 Metabolism of the Prostaglandin Endoperoxides 71 P RODUC TS OF THE 12-LIPO XYGEN ASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
P, Needleman +4 more
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C YC LOO XYGENASE PRODUC TS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 70 Prostaglandin Endoperoxide Synthase 70 Metabolism of the Prostaglandin Endoperoxides 71 P RODUC TS OF THE 12-LIPO XYGEN ASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
P, Needleman +4 more
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Preventive Medicine, 1987
Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue
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Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue
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Arachidonic acid production by microorganisms
Biotechnology and Applied Biochemistry, 1992Arachidonic acid (AA) is a natural precursor of prostaglandins, thromboxanes, leukotrienes, prostacyclins, and a large group of C20 compounds which are of intrinsic medical interest. At present, the only source of AA is animal tissues. However, it is present in several microorganisms. This review describes the production of AA by microorganisms and its
P, Bajpai, P K, Bajpai
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Preparation of deuterated arachidonic acid
Prostaglandins, 1981Publisher Summary It is reported preparation of [ 2 H 8 ]arachidonic acid from the precursor tetraacetylene eicosatetraynoic procedures gave rise to substantial double-bond isomerization and isotopic scrambling, leading to mixtures that yielded after purification only small quantities of the desired product.
D F, Taber, M A, Phillips, W C, Hubbard
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Interactions of zinc and arachidonic acid
Prostaglandins and Medicine, 1981To probe the interaction of zinc with polyunsaturated fatty acids we have studied the effect of zinc on the cooxygenation of ferrous iron and arachidonic acid. Zinc inhibited the process of cooxygenation in a concentration dependent fashion. Further evaluation of the interaction of zinc and arachidonic acid gave spectroscopic evidence that zinc, oxygen
D A, Peterson +4 more
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Renal Arachidonic Acid Metabolism
Annual Review of Physiology, 1984Renal prostaglandin synthesis has been the focus of extensive investigation during the past decade. This chapter reviews the cellular localization of renal arachidonic acid metabolism in view of the substantial recent progress in the isolation and culture of renal cell types.
M G, Currie, P, Needleman
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Glucagon and plasma arachidonic acid
Metabolism, 1965Abstract Previous work has shown the presence of a factor in the external pancreatic secretion of dogs distinct from the enzymes that affect plasma arachidonic acid. Removal of the exocrine factor by pancreatectomy or pancreatic duct ligation resulted in depression of arachidonic acid in all plasma lipid fractions which could not be corrected by ...
R, CAREN, L, CORBO
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Biological Nitration of Arachidonic Acid
Current Vascular Pharmacology, 2004When a spontaneous autoxidation of arachidonic acid to prostaglandin-like products was first described almost 40 years ago, it was thought to be an artifact that interfered with the detection of enzymatically generated prostaglandins. It has now been generally accepted that the autoxidation of arachidonic acid occurs in vivo and leads to formation of ...
Michael, Balazy, Candace D, Poff
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