Results 71 to 80 of about 13,694 (297)

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin   +11 more
wiley   +1 more source

Permissivism and the Arbitrariness Objection [PDF]

open access: yes, 2017
Permissivism says that for some propositions and bodies of evidence, there is more than one rationally permissible doxastic attitude that can be taken towards that proposition given the evidence.
Simpson, Robert Mark, Simpson, RM
core  

On the Arbitrariness of Linguistic Signs

open access: yes, 2010
There are many different opinions on the arbitrariness of linguistic signs. This paper will review these different understandings of the arbitrariness and linguistic signs and some arguments of some famous linguists over the arbitrariness of linguistic ...
ZHENG, Xiao-dan
core   +1 more source

La motivación de los actos administrativos y su control. Reflexiones críticas sobre las últimas orientaciones

open access: yesRevista Vasca de Administración Pública, 2009
The prohibition of arbitrariness, the duty to give reasons and the duty to justify decisions have become principles of main relevance in the judicial control of administrative discretion.
Eva Desdentado Daroca
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Features of attention and memory of students – generation Z in the context of digitalization

open access: yesВестник Мининского университета
Introduction. The modern information world has made adjustments to the development of cognitive functions of generations. Many researchers have noted a decrease in memory, attention, and thinking abilities. To a lesser extent, the attention of generation
V. I. Pishchik, G. A. Molokhina
doaj   +1 more source

Reference in Formal Semantics and Natural Language: A Methodological Route

open access: yesPhenomenology and Mind, 2019
In this paper, I will tackle the notion of reference of singular terms in the light of a classic analytic divide, i.e. whether its analysis, like the analysis of other basic notions, should be carried out in natural language or in the semantics of formal
Francesca Boccuni
doaj   +1 more source

Towards a Theory of Arbitrary Law-making in Migration Policy

open access: yesEtikk i Praksis: Nordic Journal of Applied Ethics, 2020
The article considers what arbitrary law-making is and what may count as arbitrary law-making in the field of migration policy. It contributes to the discussion of arbitrary law-making in relation to migration policy in two ways.
Patricia Mindus
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Linguistic arbitrariness and the ‘Nebulous’ world of vorstellung in Saussure

open access: yes, 2010
The paper discusses de Saussure’s linguistic sign as defined in the Cours de linguistique général. I first deal with his notion of arbitrariness and the assertion that Vorstellung (idée, concept) on its own is nebulous.
Ruthrof, H.
core  

Home - About - Disclaimer - Privacy