Results 71 to 80 of about 108,124 (355)

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

Advanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang, Hengji Zhan, Bolin Pan, Leli Zeng, Zehua Chen, Sen Liu, Qiang Zhang, Xuwei Hong, Junlin Lu, Xinrou Lin, Xiao Zhao, Jiajian Lai, Kaiwen Jie, Ye Li, Jianmei Zhong, Shengmeng Peng, Siting Chen, Changhao Chen, Wenlong Zhong, Shaoxu Wu, Yihang Pan, Tianxin Lin, Xu Chen   +22 more
wiley   +1 more source

Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics

mBio, 2023
Facing rapid fluctuations in their natural environment, extremophiles, like the hyperthermophilic archaeon Pyrococcus furiosus, exhibit remarkable adaptability to extreme conditions.
Felix Grünberger, Georg Schmid, Zubeir El Ahmad, Martin Fenk, Katharina Vogl, Robert Reichelt, Winfried Hausner, Henning Urlaub, Christof Lenz, Dina Grohmann   +9 more
doaj   +1 more source

Gene decay in archaea [PDF]

Archaea, 2007
The gene‐dense chromosomes of archaea and bacteria were long thought to be devoid of pseudogenes, but with the massive increase in available genome sequences, whole genome comparisons between closely related species have identified mutations that have rendered numerous genes inactive.
Christopher Smillie, Howard Ochman, M. W.J. van Passel   +2 more
openaire   +3 more sources

Bioinspired Design of Heterogenous Single‐Atomic‐Site Catalysts for Electrocatalysis and Photocatalysis

Advanced Materials, EarlyView.
This review gives a summary on the representative bioinspired single‐atomic‐site catalysts (SACs) and their applications in heterogeneous electrocatalysis and photocatalysis. The fundamentals of bioinspired design strategies are systematically discussed in the context of the first shell coordination, the second/long‐range coordination, and the outer ...
Ying Wang, Guangri Jia, Piaoping Yang, Linshan Zhang, Kwok‐Yin Wong   +4 more
wiley   +1 more source

Identification of XylR, the Activator of Arabinose/Xylose Inducible Regulon in Sulfolobus acidocaldarius and Its Application for Homologous Protein Expression

Frontiers in Microbiology, 2020
The thermophilic archaeon Sulfolobus acidocaldarius can use different carbon sources for growth, including the pentoses D-xylose and L-arabinose. In this study, we identified the activator XylR (saci_2116) responsible for the transcriptional regulation ...
Nienke van der Kolk, Alexander Wagner, Alexander Wagner, Michaela Wagner, Michaela Wagner, Bianca Waßmer, Bettina Siebers, Sonja-Verena Albers   +7 more
doaj   +1 more source

Electron cryo-microscopy reveals the structure of the archaeal thread filament

Nature Communications, 2022
Pili are filamentous appendages on the surface of bacteria and archaea, and play roles in multiple processes such as adhesion, motility and horizontal gene transfer. Here, Gaines et al. describe the structure of a new type of pilus, termed ‘thread’, from
Matthew C. Gaines, Michail N. Isupov, Shamphavi Sivabalasarma, Risat Ul Haque, Mathew McLaren, Clara L. Mollat, Patrick Tripp, Alexander Neuhaus, Vicki A. M. Gold, Sonja-Verena Albers, Bertram Daum   +10 more
doaj   +1 more source

Insect‐Microbe‐Based Laccase: Untapped Natural Resource for Industrial and Biotechnological Applications

Advanced Sustainable Systems, EarlyView.
The insect‐microbe interplay fulfills a key ecological role involving the degradation of ligninocellulose biomass. This is coordinated by the secretion of different kinds of proteins, of which ligninolytic enzymes, such as laccases (Lacs), are of prime importance.
Michael Dare Asemoloye, Adeyinka Michael Gbadebo, Tunde Sheriffdeen Bello, Olumayowa Mary Olowe, Akinlolu Olalekan Akanmu, Marta Elisabetta Eleonora Temporiti, Adeyinka Odebode, Segun Oladiran Babarinde, Tsigereda Weldemichael, Leonard Chitongo, Solveig Tosi, Mario Andrea Marchisio   +11 more
wiley   +1 more source

“Influence of plasmids, selection markers and auxotrophic mutations on Haloferax volcanii cell shape plasticity”

Frontiers in Microbiology, 2023
Haloferax volcanii and other Haloarchaea can be pleomorphic, adopting different shapes, which vary with growth stages. Several studies have shown that H.
Megha Patro, Megha Patro, Iain G. Duggin, Sonja-Verena Albers, Solenne Ithurbide   +4 more
doaj   +1 more source

The archaellum: how archaea swim [PDF]

Frontiers in Microbiology, 2015
Recent studies on archaeal motility have shown that the archaeal motility structure is unique in several aspects. Although it fulfills the same swimming function as the bacterial flagellum, it is evolutionarily and structurally related to the type IV pilus.
Sonja-Verena Albers, Sonja-Verena Albers, Ken F. Jarrell   +2 more
openaire   +5 more sources

Genomic diversity, lifestyles and evolutionary origins of DPANN archaea

FEMS Microbiology Letters, 2019
Archaea-a primary domain of life besides Bacteria-have for a long time been regarded as peculiar organisms that play marginal roles in biogeochemical cycles.
Nina Dombrowski, Jun-Hoe Lee, T. Williams, P. Offre, A. Spang   +4 more
semanticscholar   +1 more source