Results 81 to 90 of about 1,062,011 (194)

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea

Microbiology Spectrum
Archaea play a significant role in natural ecosystems and the human body. Archaeal viruses exert a considerable influence on the structure and composition of archaeal communities and their associated ecological environments.
Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang   +7 more
doaj   +1 more source

Eukaryogenesis: The Rise of an Emergent Superorganism

Frontiers in Microbiology, 2022
Although it is widely taught that all modern life descended via modification from a last universal common ancestor (LUCA), this dominant paradigm is yet to provide a generally accepted explanation for the chasm in design between prokaryotic and ...
Philip J. L. Bell
doaj   +1 more source

Influences of soil properties on archaeal diversity and distribution in the McMurdo Dry Valleys, Antarctica [PDF]

, 2011
The Antarctic Dry Valleys are characterized by extremely low temperatures, arid conditions, high salinity and virtual absence of plants. Therefore, food webs of these microbially dominated soils are among the simplest on earth making these mineral soils ...
Richter, Ingrid
core  

An archaeal chronic virus escapes the immunity of prokaryotic Argonaute

Nucleic Acids Research
Abstract Bacteria and archaea use diverse defense systems to defeat their viruses, and in turn, viruses develop anti-defense strategies to overcome the host immunity. Catalytically inactive prokaryotic Argonaute proteins constitute a family of defense systems that kill infected cells to halt viral propagation, whereas how viruses escape ...
Yu Chen, Yanqiu Liu, Keyi Tan, Ke Yang, Zhifeng Zeng, Yu Guo, Piaoran Zhang, Wenyuan Han   +7 more
openaire   +2 more sources

Lifestyle Impacts the Oral Microbiome of Classical and Post‐Classical Societies in Italy

American Journal of Biological Anthropology, Volume 191, Issue 1, September 2026.
ABSTRACT Objectives The fall of the Roman Empire (476 CE) profoundly affected the lives of its peoples due to the political, administrative, and territorial changes that occurred. The majority of written records of the time focus on the social élite, leaving larger parts of the population understudied.
Martina Farese, Markella Moraitou, Chenyu Jin, Adrian Forsythe, Ileana Micarelli, Tom van der Valk, Giorgio Manzi, Laura Parducci, Mary Anne Tafuri, Katerina Guschanski   +9 more
wiley   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, Volume 100, Issue 3, Page 655-671, September 2026.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Structural basis of RNA polymerase inhibition by viral and host factors

Nature Communications, 2021
Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design.
Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Díaz-Santín, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner   +9 more
doaj   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Viruses of archaea: Structural, functional, environmental and evolutionary genomics

, 2018
International audienceViruses of archaea represent one of the most enigmatic parts of the virosphere. Most of the characterized archaeal viruses infect extremophilic hosts and display remarkable diversity of virion morphotypes, many of which have never ...
Iranzo, Jaime, Mart Krupovic, David Prangishvili, Koonin, Eugene, Krupovic, Mart, Prangishvili, David, Jaime Iranzo, Virginija Cvirkaite-Krupovic, Cvirkaite-Krupovic, Virginija, Eugene V. Koonin   +9 more
core   +1 more source