Results 111 to 120 of about 269 (141)
The dual function of cGAS-STING signaling axis in liver diseases. [PDF]
Acta Pharmacol SinLi XJ, Qu JR, Zhang YH, Liu RP.
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Structure Diversity and Properties of Some Bola-like Natural Products. [PDF]
Mar DrugsStonik VA +4 more
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SAFETY OF ARCHAEOSOME ADJUVANTS EVALUATED IN A MOUSE MODEL*
Journal of Liposome Research, 2002 Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Halobacterium salinarum ...
Girishchandra B Patel +2 more
exaly +5 more sources
Archaeosome adjuvants: Immunological capabilities and mechanism(s) of action
Vaccine, 2008 Archaeosomes (liposomes comprised of glycerolipids of Archaea) constitute potent adjuvants for the induction of Th1, Th2 and CD8(+) T cell responses to the entrapped soluble antigen. Archaeal lipids are uniquely constituted of ether-linked isoprenoid phytanyl cores conferring stability to the membranes. Additionally, varied head groups displayed on the
Lakshmi Krishnan, G Dennis Sprott
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In vitro assessment of archaeosome stability for developing oral delivery systems
International Journal of Pharmaceutics, 2000 The in vitro stability of archaeosomes made from the total polar lipids of Methanosarcina mazei, Methanobacterium espanolae or Thermoplasma acidophilum, was evaluated under conditions encountered in the human gastrointestinal tract. At acidic pH, multilamellar vesicles (MLV) prepared from T.
Girishchandra B Patel +2 more
exaly +4 more sources
Infection and Immunity, 2000 Ether glycerolipids extracted from various archaeobacteria were formulated into liposomes (archaeosomes) possessing strong adjuvant properties. Mice of varying genetic backgrounds, immunized by different parenteral routes with bovine serum albumin (BSA ...
Lakshmi Krishnan +2 more
exaly +2 more sources
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Archaeosomes as Adjuvants for Combination Vaccines
Journal of Liposome Research, 2004The present study evaluated the potential of archaesomes, prepared from the total polar lipids extracted from Methanobrevibacter smithii, as adjuvants for combination (multivalent) vaccines. Groups of Balb/c mice were immunized subcutaneously at day 0 and 21 with one of the following vaccines: trivalent vaccine formulated by the simultaneous co ...
Patel, Girishchandra B. +3 more
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Bipolar Imidazolium-Based Lipid Analogues for Artificial Archaeosomes
Langmuir, 2021Archaeal lipids have harvested biomedical and biotechnological interest because of their ability to form membranes with low permeability and enhanced temperature and pressure stability. Because of problems in isolating archaeal lipids, chemical synthesis appears to be a suitable means of producing model lipids that mimic the biological counterparts ...
Simon Kriegler +4 more
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Archaeosomes with encapsulated antigens for oral vaccine delivery
Vaccine, 2011Traditional phosphodiester lipid vesicles (liposomes) are not stable and could be easily degraded in the gastrointestinal (GI) tract. We prepared a novel lipid based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and tested their immunogenic potentials as oral vaccine delivery ...
Zhengrong, Li +5 more
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Archaeosomes for Skin Injuries
2017This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management.
M. Vazzana +4 more
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