Results 111 to 120 of about 293 (137)
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Archaeosome Adjuvants: Immunological Capabilities and Mechanism(s) of Action
Vaccine, 2008Archaeosomes (liposomes comprised of glycerolipids of Archaea) constitute potent adjuvants for the induction of Th1, Th2 and CD8(+) T cell responses to the entrapped soluble antigen. Archaeal lipids are uniquely constituted of ether-linked isoprenoid phytanyl cores conferring stability to the membranes. Additionally, varied head groups displayed on the
Lakshmi Krishnan, G Dennis Sprott
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Archaeosomes with encapsulated antigens for oral vaccine delivery
Vaccine, 2011Traditional phosphodiester lipid vesicles (liposomes) are not stable and could be easily degraded in the gastrointestinal (GI) tract. We prepared a novel lipid based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and tested their immunogenic potentials as oral vaccine delivery ...
Zhengrong, Li +5 more
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Bipolar Imidazolium-Based Lipid Analogues for Artificial Archaeosomes
Langmuir, 2021Archaeal lipids have harvested biomedical and biotechnological interest because of their ability to form membranes with low permeability and enhanced temperature and pressure stability. Because of problems in isolating archaeal lipids, chemical synthesis appears to be a suitable means of producing model lipids that mimic the biological counterparts ...
Simon Kriegler +4 more
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Archaeosomes for Skin Injuries
2017This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management.
M. Vazzana +4 more
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Investigation of archaeosomes as carriers for oral delivery of peptides
Biochemical and Biophysical Research Communications, 2010Oral administration of peptide and protein drugs faces a big challenge partly due to the hostile gastrointestinal (GI) environment. Lipid-based delivery systems are attractive because they offer some protection for peptides and proteins. In this context, we prepared a special lipid-based oral delivery system: archaeosomes, made of the polar lipid ...
Zhengrong, Li +3 more
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In vitro evaluation of archaeosome vehicles for transdermal vaccine delivery
Journal of Liposome Research, 2017Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against ...
Yimei Jia +10 more
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Archaeosomes as means of nano-drug delivery
Reviews in Medical Microbiology, 2014Archaeosomes are a novel generation of liposomes that are made from polar ether lipids extracted from the Archaea. They have higher stabilities in acidic or alkaline pH, bile salts, high temperatures and against phospholipase, oxidation, chemical and enzymatic hydrolysis in comparison with conventional liposomes.
Eskandar Moghimipour +2 more
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In Vitro Assessment of Archaeosome Stability for Developing Oral Delivery Systems
International Journal of Pharmaceutics, 2000The in vitro stability of archaeosomes made from the total polar lipids of Methanosarcina mazei, Methanobacterium espanolae or Thermoplasma acidophilum, was evaluated under conditions encountered in the human gastrointestinal tract. At acidic pH, multilamellar vesicles (MLV) prepared from T.
G Dennis Sprott +2 more
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Archaeosomes as Self-adjuvanting Delivery Systems for Cancer Vaccines*
Journal of Drug Targeting, 2003Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a strong CD8 CTL response to entrapped
Lakshmi, Krishnan, G, Dennis Sprott
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Synthetic archaeosome adjuvants
2009Taiwan-Canada Bilateral Workshop: Glycosicence Workshop, Taipei, Taiwan, November ...
Whitfield, Dennis M., Sprott, Dennis G.
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