Results 121 to 130 of about 478 (150)
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Archaeosomes with encapsulated antigens for oral vaccine delivery
Vaccine, 2011Traditional phosphodiester lipid vesicles (liposomes) are not stable and could be easily degraded in the gastrointestinal (GI) tract. We prepared a novel lipid based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and tested their immunogenic potentials as oral vaccine delivery ...
Lihui Zhang, Qian Ding, Yuhong Xu
exaly +3 more sources
International Journal of Toxicology, 2003 Archaeosomes, liposomes made from polar ether lipids of archaea, show promise for vaccine and drug delivery applications. The potential toxicity of intravenously (14, 70, or 140 mg/kg/day for 5 consecutive days) and orally (gavaged at 55, 275, or 550 mg ...
Abdelwahab Omri, Girishchandra B Patel
exaly +2 more sources
Investigation of archaeosomes as carriers for oral delivery of peptides
Biochemical and Biophysical Research Communications, 2010Oral administration of peptide and protein drugs faces a big challenge partly due to the hostile gastrointestinal (GI) environment. Lipid-based delivery systems are attractive because they offer some protection for peptides and proteins. In this context, we prepared a special lipid-based oral delivery system: archaeosomes, made of the polar lipid ...
Yuhong Xu
exaly +3 more sources
Archaeobacterial Ether Lipid Liposomes (Archaeosomes) as Novel Vaccine and Drug Delivery Systems
Critical Reviews in Biotechnology, 1999 Liposomes are artificial, spherical, closed vesicles consisting of one or more lipid bilayer(s). Liposomes made from ester phospholipids have been studied extensively over the last 3 decades as artificial membrane models.
Girishchandra B Patel, G Dennis Sprott
exaly +1 more source
Bipolar Imidazolium-Based Lipid Analogues for Artificial Archaeosomes
Langmuir, 2021Archaeal lipids have harvested biomedical and biotechnological interest because of their ability to form membranes with low permeability and enhanced temperature and pressure stability. Because of problems in isolating archaeal lipids, chemical synthesis appears to be a suitable means of producing model lipids that mimic the biological counterparts ...
Simon Kriegler +4 more
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Archaeosomes for Skin Injuries
2017This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management.
M. Vazzana +4 more
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Archaeosome adjuvants: Immunological capabilities and mechanism(s) of action
Vaccine, 2008Archaeosomes (liposomes comprised of glycerolipids of Archaea) constitute potent adjuvants for the induction of Th1, Th2 and CD8(+) T cell responses to the entrapped soluble antigen. Archaeal lipids are uniquely constituted of ether-linked isoprenoid phytanyl cores conferring stability to the membranes. Additionally, varied head groups displayed on the
Lakshmi, Krishnan, G Dennis, Sprott
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Archaeosomes as means of nano-drug delivery
Reviews in Medical Microbiology, 2014Archaeosomes are a novel generation of liposomes that are made from polar ether lipids extracted from the Archaea. They have higher stabilities in acidic or alkaline pH, bile salts, high temperatures and against phospholipase, oxidation, chemical and enzymatic hydrolysis in comparison with conventional liposomes.
Eskandar Moghimipour +2 more
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Archaeosomes as Self-adjuvanting Delivery Systems for Cancer Vaccines*
Journal of Drug Targeting, 2003Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a strong CD8 CTL response to entrapped
Lakshmi, Krishnan, G, Dennis Sprott
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