Results 81 to 90 of about 123,827 (273)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Architecture as a process. Metamorphoses of style in the time and space

open access: yesПроект Байкал
The development of architecture of modernism and postmodernism is considered on the example of brutalism style as an oscillating process between the aspiration to severe truthfulness and the predominance of decorativeness.
Константин Лидин
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Design and quality criteria for archetype analysis

open access: yesEcology and Society, 2019
A key challenge in addressing the global degradation of natural resources and the environment is to effectively transfer successful strategies across heterogeneous contexts.
Klaus Eisenack   +8 more
doaj   +1 more source

The knowledge management kaleidoscope: Keeping stakeholders and their expectations in focus [PDF]

open access: yes, 2010
information systems field. Over many years the roots and foundations of the definition of knowledge and its constructs have upheld the view that knowledge is an amorphous entity to be harnessed in its abundance.
Braganza, A, Sharif, AM
core  

Water resources management in a homogenizing world: Averting the Growth and Underinvestment trajectory [PDF]

open access: yes, 2014
Biotic homogenization, a de facto symptom of a global biodiversity crisis, underscores the urgency of reforming water resources management to focus on the health and viability of ecosystems.
Hjorth, P   +4 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The Joint IGNTP/INTF Editio Critica Maior of the Gospel of John: its goals and their significance for New Testament scholarship [PDF]

open access: yes, 2005
Conference paper delivered at SNTS Annual Meeting in Halle, Germany, August ...
Parker, D.C., Wachtel, Klaus
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

ARCHETYPE AND LOGOS OF FURNACE AND FIREPLACE

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics, 2019
The article is literary in nature: the example of the furnace shows the difference between the logos and the archetype, as well as the principles of modifying the logos into an archetype.
Svetlana V. Gerasimova
doaj   +1 more source

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