Results 71 to 80 of about 124,672 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Locke's Criterion for the Reality of Ideas: Unambiguous but Untenable [PDF]

, 1997
The paper argues against the claim held, e.g., by Leibniz, that Locke employs a double standard for determining whether an object before the mind (i.e., an idea) is real.
de Waal, Cornelis
core  

The Archetype of Polish Political Culture in Andrzej Sapkowski's The Witcher Saga

Journal of Modern Science
Objectives The aim of this article is to discuss the universe of The Witcher from the perspective of the broadly understood history of ideas, particularly in the context of research on the archetype of Polish political culture. The author ponders to what
Agnieszka Katarzyna Puszkow-Bańka
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Unsupervised Learning of Artistic Styles with Archetypal Style Analysis [PDF]

, 2018
In this paper, we introduce an unsupervised learning approach to automatically discover, summarize, and manipulate artistic styles from large collections of paintings.
Mairal, Julien, Schmid, Cordelia, Wynen, Daan   +2 more
core   +2 more sources

FM 047-02: a collisional pair of galaxies with a ring [PDF]

, 2013
Aims. We investigate the nature of the galaxy pair FM 047-02, which has been proposed as an archetype of the Solitaire types of peculiar (collisional) ring galaxies. Methods.
da Rocha-Poppe, P. C., de Oliveira-Abans, M., Faundez-Abans, M., Fernandes, I. F., Fernandes-Martin, V. A., Krabbe, A. C.   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Archetype analysis in sustainability research: methodological portfolio and analytical frontiers

Ecology and Society, 2019
In sustainability research, archetype analysis reveals patterns of factors and processes that repeatedly shape social-ecological systems. These patterns help improve our understanding of global concerns, including vulnerability, land management, food ...
Diana Sietz, Ulrich Frey, Matteo Roggero, Yanqing Gong, Nicholas Magliocca, Rong Tan, Peter Janssen, TomᚠVáclavík   +7 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Strategies for expressing Chinese patriotic sentiment in national brand food packaging: a case study of Wahaha brand

Shipin yu jixie
The article begins by interpreting the essence of patriotic sentiment as a sense of community with a shared destiny, which can be shaped into perceptible expressions through rich design elements.
HUANG Shujie, HUANG Jun
doaj   +1 more source